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1405-20-5

1405-20-5 structure
1405-20-5 structure
  • Name: Polymyxin B Sulfate
  • Chemical Name: Polymyxin B sulfate
  • CAS Number: 1405-20-5
  • Molecular Formula: C55H96N16O13.H2SO4(PolymyxinB2Sulfate)
  • Molecular Weight: 1287.53 (PolymyxinB2Sulfate)
  • Catalog: API Antibiotics Other antibiotics
  • Create Date: 2018-02-04 08:00:00
  • Modify Date: 2025-08-21 16:37:03
  • Polymyxin B Sulfate is a cationic surfactant antibiotic agent. A mixture of polymyxins B1 and B2, increases the permeability of the cell membrane.In vitro: RB50 is resistant to killing by polymyxin B at concentrations up to 100 μg/ml.
Name Polymyxin B sulfate
Synonyms Octanamide, N-[3-amino-1-[[[1-[[[3-amino-1-[[[6,9,18-tris(2-aminoethyl)-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-15-(phenylmethyl)-1,4,7,10,13,16,19-heptaazacyclotricos-21-yl]amino]carbonyl]propyl]amino]carbonyl]-2-hydroxypropyl]amino]carbonyl]propyl]-6-methyl-, sulfate (1:1) (salt)
MASTIMYXIN
MYP SUPPLEMENT
N-[4-Amino-1-({1-[(4-amino-1-oxo-1-{[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-isobutyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]amino}-2-butanyl)amino]-3-hydroxy-1-oxo-2-butanyl}amino)-1-oxo-2-butanyl]-6-methyloctanamide sulfate (1:1)
APPLISORB
PolymyxineBsulfate
POLYMIXIN B SULPHATE
PolymyxinBSulfate(sterile,non-sterile)
N-[4-Amino-1-({1-[(4-amino-1-oxo-1-{[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-isobutyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]amino}-2-butanyl)amino]-3-hydroxy-1-oxo-2-butanyl}amino)-1-oxo-2-butanyl]-6-methyloctanamide sulfate (salt)
POLYMYXIN B
POLYMYXIN B (PMB)
POLYMIXIN B SULFATE
Polymyxin B Sulfate
AEROSPORIN
EINECS 215-774-7
octanimidic acid, N-[3-amino-1-[(Z)-[[1-[(E)-[[3-amino-1-[(E)-hydroxy[[(1Z,13E,19E)-6,9,18-tris(2-aminoethyl)-2,5,8,11,14,17,20-heptahydroxy-3-(1-hydroxyethyl)-12-(2-methylpropyl)-15-(phenylmethyl)-1,4,7,10,13,16,19-heptaazacyclotricosa-1,4,7,10,13,16,19-heptaen-21-yl]imino]methyl]propyl]imino]hydroxymethyl]-2-hydroxypropyl]imino]hydroxymethyl]propyl]-6-methyl-, (1E)-, sulfate (1:1) (salt)
MFCD00270609
Polymyxin B (Sulfate)
Description Polymyxin B Sulfate is a cationic surfactant antibiotic agent. A mixture of polymyxins B1 and B2, increases the permeability of the cell membrane.In vitro: RB50 is resistant to killing by polymyxin B at concentrations up to 100 μg/ml.
Related Catalog
References

[1]. Rolin O et al. Enzymatic modification of lipid A by ArnT protects Bordetella bronchiseptica against cationic peptides and is required for transmission. Infect Immun. 2014 Feb;82(2):491-9.

[2]. Pye CC et al. Evaluation of biofilm production by Pseudomonas aeruginosa from canine ears and the impact of biofilm on antimicrobial susceptibility in vitro.Vet Dermatol. 2013 Aug;24(4):446-9
Boiling Point 1651ºC at 760 mmHg
Melting Point 217-220°C (dec.)
Molecular Formula C55H96N16O13.H2SO4(PolymyxinB2Sulfate)
Molecular Weight 1287.53 (PolymyxinB2Sulfate)
Flash Point 952.3ºC
PSA 573.64000
LogP 2.54990
Appearance powder
Vapour Pressure 0mmHg at 25°C
Storage condition 2-8°C
Water Solubility H2O: 50 mg/mL

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TR1150000
CHEMICAL NAME :
Polymyxin B sulfate
CAS REGISTRY NUMBER :
1405-20-5
LAST UPDATED :
199504
DATA ITEMS CITED :
13
MOLECULAR FORMULA :
C43-H82-N16-O12.xH2-O4-S
MOLECULAR WEIGHT :
1701.97

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
790 mg(base)/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
20500 ug(base)/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
59500 ug(base)/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5400 ug(base)/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
8 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intracerebral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
320 ug/kg
TOXIC EFFECTS :
Behavioral - coma
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
58 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation test systems - not otherwise specified
TEST SYSTEM :
Yeast - Saccharomyces cerevisiae
DOSE/DURATION :
5 mg/L
REFERENCE :
AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972- Volume(issue)/page/year: 2,36,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81938 No. of Facilities: 152 (estimated) No. of Industries: 4 No. of Occupations: 6 No. of Employees: 967 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9499 No. of Facilities: 383 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1149 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81938 No. of Facilities: 1842 (estimated) No. of Industries: 19 No. of Occupations: 18 No. of Employees: 173376 (estimated) No. of Female Employees: 145041 (estimated)
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Precautionary Statements P301 + P312 + P330
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn: Harmful;
Risk Phrases R22
Safety Phrases S22-S24/25
RIDADR 3249
WGK Germany 3
RTECS TR1150000
Packaging Group III
Hazard Class 6.1(b)
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