70967-90-7

70967-90-7 structure

Name: MeOSuc-Ala-Ala-Pro-Val-pNA
Chemical Name: methyl 4-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-3-methyl-1-(4-nitroanilino)-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoate
CAS Number: 70967-90-7
Molecular Formula: C₂₇H₃₈N₆O₉
Molecular Weight: 590.62500
Catalog: Research Areas Others
Create Date: 2018-10-05 12:11:34
Modify Date: 2026-06-30 20:19:41
MeOSuc-Ala-Ala-Pro-Val-pNA is a sensitive fluorogenic substrate of human leukocyte and porcine pancreatic elastase[1].

Name	methyl 4-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-3-methyl-1-(4-nitroanilino)-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoate
Synonyms	Methoxysuccinyl-Ala-Ala-Pro-Val-p-nitroanilide MeOSuc-AAPV-pNA, Chromogenic Substrate LEUKOCYTE ESTERASE SUBSTRATE MeOSuc-Ala-Ala-Pro-Val-p-NA N-(Methoxysuccinyl)-Ala-Ala-Pro-Val 4-nitroanilide, N-(Methoxysuccinyl)-L-alanyl-L-alanyl-L-prolyl-L-valine 4-nitroanilide MeO-Suc-Ala-Ala-Pro-Val-(p-nitroanilide) N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL P-NITROANILIDE N-(METHOXYSUCCINYL)-L-ALANYL-L-ALANYL-L-PROLYL-L-VALINE 4-NITROANILIDE MeOSuc-AAPV-pNA EINECS 232-670-7 N(methoxysuccinyl)-L-alanyl-L-alanyl-L-prolyl-L-valine NA Elastase Substrate I, Colorimetric - - Calbiochem Methyl 4-(((S)-1-(((S)-1-((S)-2-(((S)-3-methyl-1-((4-nitrophenyl)amino)-1-oxobutan-2-yl)cbamoyl)pyrrolidin-1-yl)-1-oxopropan-2-yl)amino)-1-oxopropan-2-yl)amino)-4-oxobutanoate N-(Methoxysuccinyl)-Ala-Ala-Pro-Val 4-nitroanilide M4765 N-3-carbomethoxypropanoyl-alanyl-alanyl-prolyl-valine p-nitroanilide N-(Methoxysuccinyl)-L-alanyl-L-alanyl-L-prolyl-L-valine 4-nitroanilide Methoxysuccinyl-Ala-Ala-Pro-Val-p-nitroanilide - - Calbiochem METHOXYSUCCINYL-ALA-ALA-PRO-VAL-P-NITROANILIDE, METHANOL ADDUCT MeOSuc-AAPV-PNA ELASTASE SUBSTRATE I, COLORIMETRIC L-Valinamide, N-(4-methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-L-prolyl-N-(4-nitrophenyl) MEO-SUC-ALA-ALA-PRO-VAL-PANITROANILIDE methyl 4-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-3-methyl-1-(4-nitroanilino)-1-oxobutan-2-yl]cbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoate MFCD00077137 MEOSUC-ALA-ALA-PRO-VAL-PNA N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL P-NITROANILIDE, BIOCHEMIKA N-methoxysuccinyl-Ala-Ala-Pro-Val-p-nitroanilide N-methoxysuccinyl-alanyl-alanyl-prolyl-valine-4-nitroanilide N-(4-Methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-L-prolyl-N-(4-nitrophenyl)-L-valinamide

Description	MeOSuc-Ala-Ala-Pro-Val-pNA is a sensitive fluorogenic substrate of human leukocyte and porcine pancreatic elastase[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	MeOSuc-Ala-Ala-Pro-Val-pNA exhibits kc/Km values of 185,000, 15,000, 58,000 and 330,000 M-1s-1 at 0.10 M phosphate, 0.20 M Mes, 0.10 M phosphate and 0.04 M phosphate, respectively, for reactions of human leukocyte elastase[2].
References	[1]. Castillo MJ, et al. Sensitive substrates for human leukocyte and porcine pancreatic elastase: a study of the merits of various chromophoric and fluorogenic leaving groups in assays for serine proteases. Anal Biochem. 1979 Oct 15;99(1):53-64. [2]. Ross L. Stein, et al. Catalysis by human leukocyte elastase. Rate-limiting deacylation for specific p-nitroanilides and amides. J. Am. Chem. Soc. 1984, 106, 3, 796-798.

Density	1.297g/cm3
Boiling Point	908.4ºC at 760 mmHg
Molecular Formula	C₂₇H₃₈N₆O₉
Molecular Weight	590.62500
Flash Point	503.2ºC
Exact Mass	590.27000
PSA	208.83000
LogP	2.33450
Index of Refraction	1.567
Storage condition	20°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport

186581-53-3