Name | α-asarone |
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Synonyms |
Benzene, 1,2,4-trimethoxy-5-[(1E)-1-propen-1-yl]-
trans-1,2,4-Trimethoxy-5-(1-propenyl)benzene Asarin 1,2,4-trimethoxy-5-[(1E)-prop-1-en-1-yl]benzene EINECS 220-743-6 A-Asarion trans-1,2,4-Trimethoxy-5-(1-propenyl)benzene,trans-1-Propenyl-2,4,5-trimethoxybenzene Asaron alpha-asarone (E)-Asarone benzene, 1,2,4-trimethoxy-5-[(1E)-1-propenyl]- a-Asarone α-Asarone 1,2,4-Trimethoxy-5-[(1E)-1-propen-1-yl]benzene ASARONE,A MFCD00064457 1,2,4-Triméthoxy-5-[(1E)-1-propèn-1-yl]benzène trans-Asarone trans-2,4,5-trimethoxyphenylpropene Asarone trans-asaron Etherophenol |
Description | Alpha-Asarone is one of the main psychoactive compounds, and possesses an antidepressant-like activity in mice.IC50 value:Target:In vitro: The results indicated that α-asarone significantly attenuated the LPS-stimulated increase in neuroinflammatory responses and suppressed pro-inflammatory cytokine production in BV-2 cells. Mechanistic study revealed that α-asarone?inhibited the LPS-stimulated activation via regulation of nuclear factor kappa-B by blocking degradation of inhibitor kappa B-alpha signaling in BV-2 microglial cells. [2]In vivo: The present results reveal that the acute treatment of α-asarone elicited biphasic responses on immobility such that the duration of the immobility time is significantly reduced at lower doses (15 and 20 mg/kg, i.p.) but increased at higher doses (50 and 100 mg/kg, i.p.) in the TST. Besides, α-asarone at higher doses (50 and 100 mg/kg, i.p.) significantly decreased the spontaneous locomotor activity.[1] |
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Related Catalog | |
References |
Density | 1.0±0.1 g/cm3 |
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Boiling Point | 296.0±0.0 °C at 760 mmHg |
Melting Point | 57-61 °C(lit.) |
Molecular Formula | C12H16O3 |
Molecular Weight | 208.254 |
Flash Point | 107.7±23.8 °C |
Exact Mass | 208.109940 |
PSA | 27.69000 |
LogP | 2.98 |
Vapour Pressure | 0.0±0.6 mmHg at 25°C |
Index of Refraction | 1.526 |
Storage condition | −20°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
|
Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H302 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
Hazard Codes | Xn: Harmful; |
Risk Phrases | R22 |
Safety Phrases | S22-S24/25 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
RTECS | DC2975000 |
Packaging Group | II; III |
Hazard Class | 4.1 |
Precursor 8 | |
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DownStream 5 | |