2673-72-5

2673-72-5 structure

Name: D-erythro-Sphingosine hydrochloride
Chemical Name: D-erythro-Sphingosine hydrochloride
CAS Number: 2673-72-5
Molecular Formula: C₁₈H₃₈ClNO₂
Molecular Weight: 335.95300
Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
Create Date: 2018-09-16 18:56:25
Modify Date: 2024-01-16 16:14:39
D-erythro-Sphingosine (Erythrosphingosine) hydrochloride is a specific TRPM3 activator. D-erythro-Sphingosine also induces retinoblastoma protein dephosphorylation[1][2].

Name	D-erythro-Sphingosine hydrochloride
Synonyms	d-sphingosine hcl

Description	D-erythro-Sphingosine (Erythrosphingosine) hydrochloride is a specific TRPM3 activator. D-erythro-Sphingosine also induces retinoblastoma protein dephosphorylation[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Neurological Disease
Target	TRPM3 Retinoblastoma protein
In Vitro	Extracellular application of D-erythro-Sphingosine (20 μM) induces an increase in [Ca2+]i in TRPM3-transfected HEK293 cells within 20 to 30 s after start of application, whereas nontransfected control cells (NT) shows only very small responses[1]. D-erythro-Sphingosine (10 μM) induces currents through TRPM3[1]. Induction of retinoblastoma protein dephosphorylation by D-erythro-Sphingosine (500 nM; 24 h) precede inhibition of growth and a specific arrest in the G0/G1 phase of the cell cycle[2].