100858-33-1
- Name: Benzyl 3-hydroxy-1-pyrrolidinecarboxylate
- Chemical Name: (R)-1-Carbobenzoxy-3-pyrrolidinol
- CAS Number: 100858-33-1
- Molecular Formula: C12H15NO3
- Molecular Weight: 221.252
- Create Date: 2018-12-16 12:12:05
- Modify Date: 2026-08-27 13:32:13
| Name | (R)-1-Carbobenzoxy-3-pyrrolidinol |
|---|---|
| Synonyms |
benzyl (3R)-3-hydroxypyrrolidine-1-cboxylate
(R)-1-Benzyloxycarbonyl-3-pyrrolidinol (3R)-N-CBZ-3-pyrrolidinol (R)-1-Benzyloxycbonyl-3-hydroxypyrrolidine (R)-()-1-Cbz-3-pyrrolidinol (R)-1-Cbobenzoxy-3-hydroxypyrrolidine (R)-(-)-1-Cbz-3-Pyrrolidinol (R)-(-)-1-Cbz-3-pyrroL 1-Pyrrolidinecboxylic acid, 3-hydroxy-, phenylmethyl ester, (3R) Benzyl 3-hydroxypyrrolidine-1-carboxylate (R)-1-Cbz-3-pyrrolidinol ee (R)-1-Benzyloxycbonyl-3-pyrrolidinol, (R)-1-Cbobenzoxy-3-pyrrolidinol, (R)-N-Z-3-Pyrrolidinol Benzyl (R)-3-hydroxypyrrolidine-1-cboxylate (R)-1-Cbzl-3-pyrrolidinol (R)-(-)-1-Cbz-3-pyrrolidinol (R)-(3-hydroxypyrrolidin-1-yl)(phenyl)methanone (R)-1-Cbobenzoxy-3-pyrrolidinol > (R)-(−)-1-Cbz-3-pyrrolidinol (R)-3-Hydroxy-pyrrolidine-1-cboxylic acid benzyl ester (R)-benzyl 3-hydroxypyrrolidine-1-cboxylate (R)-1-Cbobenzoxy-3-hydroxypyrrolidine (R)-1-Cbz-3-pyrrolidinol (R)-N-Cbz-3-hydroxypyrroline N-Cbz-3(R)-hydroxypyrrolidine (S)-N-Boc-3-hydroxypyrroline,e.e (R)-N-Z-3-Pyrrolidinol 1-Pyrrolidinecarboxylic acid, 3-hydroxy-, phenylmethyl ester R-1-N-CBZ-3- hydroxy-pyrroline (R)-1-Carbobenzoxy-3-hydroxypyrrolidine (R)-1-Cbz-3-pyrrolidinol (R)-1-Cbz-3-pyrrolidinol, ee benzyl (3R)-3-hydroxypyrrolidine-1-carboxylate (R)-(-)-1-CBZ-3-HYDROXY-PYRROLIDINE (R)-N-Cbz-3-hydroxypyrrolidine |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 370.7±42.0 °C at 760 mmHg |
| Melting Point | 74-79ºC |
| Molecular Formula | C12H15NO3 |
| Molecular Weight | 221.252 |
| Flash Point | 178.0±27.9 °C |
| Exact Mass | 221.105194 |
| PSA | 49.77000 |
| LogP | 0.54 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Index of Refraction | 1.589 |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H315-H319-H335 |
| Precautionary Statements | P261-P301 + P310-P305 + P351 + P338 |
| Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
| Hazard Codes | T:Toxic; |
| Risk Phrases | R25;R36/37/38 |
| Safety Phrases | S26-S45 |
| RIDADR | UN 2811 |
| WGK Germany | 3.0 |
| Hazard Class | 6.1 |
| HS Code | 2933990090 |
|
~10%
100858-33-1 |
| Literature: FOB SYNTHESIS; CHOI, Woo-Baeg; KIM, Deog-Il; GRUSZECKA-KOWALIK, Ewa; JOO, Hyung-Yeul; LIU, Shuangpei; MAO, Shuli; LI, Yongfeng Patent: WO2011/160020 A2, 2011 ; Location in patent: Page/Page column 57 ; |
|
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| Literature: Sanchez; Domagala; Heifetz; Priebe; Sesnie; Trehan Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1764 - 1773 |
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~64%
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| Literature: Li; Feiten; Chang; Duetz; Van Beilen; Witholt Journal of Organic Chemistry, 2001 , vol. 66, # 25 p. 8424 - 8430 |
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| Literature: US5977381 A1, ; |
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| Literature: Tomori, Hiroshi; Shibutani, Kuniko; Ogura, Katsuyuki Bulletin of the Chemical Society of Japan, 1996 , vol. 69, # 1 p. 207 - 215 |
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| Literature: Journal of the American Chemical Society, , vol. 108, # 8 p. 2049 - 2054 |
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| Literature: Bulletin of the Chemical Society of Japan, , vol. 69, # 1 p. 207 - 215 |
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| Literature: Bulletin of the Chemical Society of Japan, , vol. 69, # 1 p. 207 - 215 |
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| Literature: Advanced Synthesis and Catalysis, , vol. 352, # 18 p. 3380 - 3390 |
| Precursor 7 | |
|---|---|
| DownStream 10 | |
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |