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92-84-2

92-84-2 structure
92-84-2 structure
  • Name: Phenothiazine
  • Chemical Name: 10H-phenothiazine
  • CAS Number: 92-84-2
  • Molecular Formula: C12H9NS
  • Molecular Weight: 199.272
  • Catalog: API Antiparasitic drug Antiprotozoal
  • Create Date: 2018-02-05 08:00:00
  • Modify Date: 2024-01-01 20:53:39
  • Phenothiazine is an antibiotic which has insecticidal, fungicidal, antibacterial and anthelmintic activities. Phenothiazine also can be used for the research of neurological diseases[1][2].
Name 10H-phenothiazine
Synonyms Thiodiphenylamine
Dibenzothiazine
Phenosan
EINECS 202-196-5
Antiverm
Phenthiazine
Agrazine
PHENOTHIAZINE
Feeno
MFCD00005015
Description Phenothiazine is an antibiotic which has insecticidal, fungicidal, antibacterial and anthelmintic activities. Phenothiazine also can be used for the research of neurological diseases[1][2].
Related Catalog
References

[1]. Mitchell SC, et, al. The toxicity of phenothiazine. Drug Metabol Drug Interact. 1994;11(3):201-35.

[2]. Ohlow MJ, et, al. Phenothiazine: the seven lives of pharmacology's first lead structure. Drug Discov Today. 2011 Feb;16(3-4):119-31.
Density 1.2±0.1 g/cm3
Boiling Point 371.0±12.0 °C at 760 mmHg
Melting Point 184 °C
Molecular Formula C12H9NS
Molecular Weight 199.272
Flash Point 178.2±19.6 °C
Exact Mass 199.045563
PSA 37.33000
LogP 4.15
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.675
Stability Stable. Combustible. Incompatible with strong oxidizing agents, strong acids. May discolour upon exposure to light.
Water Solubility 2 mg/L (25 ºC)

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SN5075000
CHEMICAL NAME :
Phenothiazine
CAS REGISTRY NUMBER :
92-84-2
BEILSTEIN REFERENCE NO. :
0143237
LAST UPDATED :
199712
DATA ITEMS CITED :
28
MOLECULAR FORMULA :
C12-H9-N-S
MOLECULAR WEIGHT :
199.28
WISWESSER LINE NOTATION :
T C666 BM ISJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - child
DOSE/DURATION :
425 mg/kg/5D
TOXIC EFFECTS :
Behavioral - headache Liver - jaundice, other or unclassified Blood - normocytic anemia
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 242,86,1942
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Behavioral - antipsychotic
REFERENCE :
DNEUD5 Developments in Neuroscience (Amsterdam). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1977- Volume(issue)/page/year: 7,45,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
178 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00586
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1104,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - cattle
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1104,1986
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Bird - wild bird species
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JACSAT Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879- Volume(issue)/page/year: 66,888,1944 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1250 mg/kg
SEX/DURATION :
female 1-22 day(s) after conception
REFERENCE :
AJANA2 American Journal of Anatomy. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1-192, 1901-91. Volume(issue)/page/year: 110,29,1962 *** REVIEWS *** ACGIH TLV-TWA 5 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW PLMJAP Pahlavi Medical Journal. (Shiraz, Iran) V.1-9, 1970-78. Volume(issue)/page/year: 6,160,1975 TOXICOLOGY REVIEW CLCHAU Clinical Chemistry (Winston-Salem, NC). (American Assoc. for Clinical Chemistry, 1725 K St., NW, Washington, DC 20006) V.1- 1955- Volume(issue)/page/year: 19,361,1973 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 5 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,204,1971 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 5 mg/m3;Skin JAN 1993 OEL-BELGIUM:TWA 5 mg/m3;Skin JAN 1993 OEL-DENMARK:TWA 5 mg/m3;Skin JAN 1993 OEL-FINLAND:TWA 5 mg/m3;STEL 10 mg/m3;Skin JAN 1993 OEL-FRANCE:TWA 5 mg/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 5 mg/m3;Skin JAN 1993 OEL-THE PHILIPPINES:TWA 5 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 5 mg/m3;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO PHENOTHIAZINE-air:10H TWA 5 mg/m3 (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84116 No. of Facilities: 175 (estimated) No. of Industries: 5 No. of Occupations: 15 No. of Employees: 5639 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84116 No. of Facilities: 5473 (estimated) No. of Industries: 54 No. of Occupations: 68 No. of Employees: 88048 (estimated) No. of Female Employees: 8791 (estimated)
Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Warning
Hazard Statements H302-H317-H373-H412
Precautionary Statements P273-P280
Target Organs Blood
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xi:Irritant;N:Dangerousfortheenvironment;
Risk Phrases R36/38;R43;R51/53
Safety Phrases S26-S36-S61-S36/37/39-S29
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS SN5075000
HS Code 29343090
HS Code 2934300000
Summary 2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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title: CAS No. 92-84-2 | Chemsrc address: https://m.chemsrc.com/en/baike/1029422.html

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