Name | 4-oxo-4-(2,4,5-triethoxyphenyl)butanoic acid |
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Synonyms |
2,4,5-Triethoxy-g-oxobenzenebutanoic Acid
Colibil Benzenebutanoic acid, 2,4,5-triethoxy-γ-oxo- MFCD00865221 4-Oxo-4-(2,4,5-triethoxyphenyl)butanoic acid Trepibutone AA 149 Triethoxybenzoylpropionate Supacal |
Description | Trepibutone (AA 149) increases secretion of bile and pancreatic juice, and accelerates flaccidity of the smooth muscle in the gastrointestinal tract. Trepibutone can be used for the research of cholecystitis and functional gastrointestinal disorders[1][2]. |
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Related Catalog | |
In Vitro | Trepibutone (1-1000 μM) markedly relaxes the sphincter of Oddi and duodenum[1]. |
In Vivo | Trepibutone (1-20 mg/kg; i.v. once) dose-dependently increases bile flow[2]. Trepibutone (10 mg/kg; i.v. 3 h after 14C-erythritol injection) stimulates canalicular bile formation without enhancement of water secretion and inhibition of bile reabsorption in the biliary ductules and ducts[2]. Animal Model: Anesthetized beagle dogs[2] Dosage: 1-20 mg/kg Administration: Intravenous injection; 1-20 mg/kg once Result: Dose-dependently increased the bile flow of dogs and showed the peak increases of the bile flow with a dose of 10 mg/kg . Animal Model: Beagle dogs with 14C-erythritol injection[2] Dosage: 10 mg/kg Administration: Intravenous injection; 10 mg/kg; 3 h after 14C-erythritol injection Result: Increased the bile flow associated with canalicular bile flow and stimulated canalicular bile formation. |
Density | 1.1±0.1 g/cm3 |
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Boiling Point | 498.6±45.0 °C at 760 mmHg |
Melting Point | 146-150ºC |
Molecular Formula | C16H22O6 |
Molecular Weight | 310.342 |
Flash Point | 179.9±22.2 °C |
Exact Mass | 310.141632 |
PSA | 82.06000 |
LogP | 3.18 |
Vapour Pressure | 0.0±1.3 mmHg at 25°C |
Index of Refraction | 1.512 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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HS Code | 2918990090 |
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~% 41826-92-0 |
Literature: Murata; Satoh; Nohara; et al. European Journal of Medicinal Chemistry, 1977 , vol. 12, # 1 p. 17 - 20 |
Precursor 2 | |
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DownStream 1 | |
HS Code | 2918990090 |
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Summary | 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |