443302-08-7

443302-08-7 structure

Name: ZnAF-1F
Chemical Name: 5-[2-[bis(pyridin-2-ylmethyl)amino]ethylamino]-2-(2,7-difluoro-3-hydroxy-6-oxoxanthen-9-yl)benzoic acid
CAS Number: 443302-08-7
Molecular Formula: C₃₄H₂₆F₂N₄O₅
Molecular Weight: 608.59100
Catalog: Research Areas Others
Create Date: 2018-12-29 11:02:10
Modify Date: 2024-01-24 11:39:02
ZnAF-1F is a potent fluorophore for with an Kd value of 2.2 nM. ZnAF-1F can be used as fluorescent probes for Zn2+ in cells. ZnAF-1F shows λ excitation of 489 nm and λ emission of 514 nm[1][2][3].

Name	5-[2-[bis(pyridin-2-ylmethyl)amino]ethylamino]-2-(2,7-difluoro-3-hydroxy-6-oxoxanthen-9-yl)benzoic acid
Synonyms	ZnAF-1F 5-{2-[Bis(2-pyridylmethyl)amino]ethylamino}-2',7'-difluorofluorescein

Description	ZnAF-1F is a potent fluorophore for with an Kd value of 2.2 nM. ZnAF-1F can be used as fluorescent probes for Zn2+ in cells. ZnAF-1F shows λ excitation of 489 nm and λ emission of 514 nm[1][2][3].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	ZnAF-1F (1 µM) shows an Kon value of 3.5106 M-1s-1, and an Koff value of 7.710-3 s-1 in 100mM HEPES buffer[1]. ZnAF-1F is a Zn sensors in neutral and slightly acidic conditions[2].
References	[1]. Hirano T, et al. Improvement and biological applications of fluorescent probes for zinc, ZnAFs. J Am Chem Soc. 2002 Jun 12;124(23):6555-62. [2]. Zhaohua Dai, et al. Tailoring tripodal ligands for zinc sensing. New J. Chem., 2007,31, 1708-1718. [3]. Que EL, et al. Metals in neurobiology: probing their chemistry and biology with molecular imaging. Chem Rev. 2008 May;108(5):1517-49.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport