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Product Name: Guanicaine
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537-05-3

537-05-3 structure

537-05-3 structure

Name: Guanicaine
Chemical Name: 2-(4-ethoxyphenyl)-1,3-bis(4-methoxyphenyl)guanidine,hydrochloride
CAS Number: 537-05-3
Molecular Formula: C₂₃H₂₆ClN₃O₃
Molecular Weight: 427.92400
Create Date: 2018-08-05 19:23:24
Modify Date: 2025-08-29 19:50:09

Name	2-(4-ethoxyphenyl)-1,3-bis(4-methoxyphenyl)guanidine,hydrochloride
Synonyms	Guanicaine Acoin Diparaanisyl-monophenethyl-guanidin-hydrochlorid [German] 2-(4-Ethoxyphenyl)-1,3-bis(4-methoxyphenyl)guanidine hydrochloride Dianisyl-monophenethylguanidine hydrochloride Akoin hydrochlorid [German] Phenodianisyl Phenodianisyl hydrochloride Acoine Acoin hydrochloride

Boiling Point	545.9ºC at 760mmHg
Molecular Formula	C₂₃H₂₆ClN₃O₃
Molecular Weight	427.92400
Flash Point	284ºC
Exact Mass	427.16600
PSA	64.11000
LogP	6.26220

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF2000000

CHEMICAL NAME :: Guanidine, 2-(p-ethoxyphenyl)-1,3-bis(p-methoxyphenyl)-, hydrochloride

CAS REGISTRY NUMBER :: 537-05-3

LAST UPDATED :: 199012

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C23-H25-N3-O3.Cl-H

MOLECULAR WEIGHT :: 427.97

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Behavioral - excitement

REFERENCE :: HDTU** "Pharmakologische Prufung von Analgetika, Dissertation," Herrlen, G., Pharmakologischen Institut der Universitat Tubingen, Fed. Rep. Ger., 1933 Volume(issue)/page/year: -,-,1933

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 53 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic

REFERENCE :: WDMU** "Vergleichend-pharmakologische Untersuchungen ueber die haemolytische Wirkung und die Toxizitat der Lokalanaesthetika, Dissertation," Walther, M., Pharmakologischen Instit Martin Luther-Universitat Halle-Wittenburg, Ger. Dem. Rep., 1936 Volume(issue)/page/year: -,-,1936

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1291,1935

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MEIEDD Merck Index. (Merck & Co., Inc., Rahway, NJ 07065) 10th ed. 1983. For publisher information, see 85KYAH. Volume(issue)/page/year: 10,1043,1983

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1291,1935

HS Code	2925290090

HS Code	2925290090
Summary	2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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