84467-94-7

84467-94-7 structure

Name: Desmethyl Sibutramine hydrochloride
Chemical Name: 1-[1-(4-chlorophenyl)cyclobutyl]-N,3-dimethylbutan-1-amine,hydrochloride
CAS Number: 84467-94-7
Molecular Formula: C₁₆H₂₅Cl₂N
Molecular Weight: 302.28
Catalog: Signaling Pathways Neuronal Signaling Serotonin Transporter
Create Date: 2016-04-17 04:25:32
Modify Date: 2024-01-09 17:45:02
Desmethyl Sibutramine hydrochloride, the secondary metabolite of Sibutramine, is an orally active norepinephrine transporter (NET) and serotonin transporter (SERT) inhibitor. Desmethyl Sibutramine hydrochloride can be used in the research of obesity and appetite suppressant[1][2][3][4].

Name	1-[1-(4-chlorophenyl)cyclobutyl]-N,3-dimethylbutan-1-amine,hydrochloride
Synonyms	N-Desmethylsibutramine hydrochloridehydrochloride Desmethyl Sibutramine,Hydrochloride Salt Desmethylsibutramine hydrochloride mono-Desmethylsibutramine hydrochloride

Description	Desmethyl Sibutramine hydrochloride, the secondary metabolite of Sibutramine, is an orally active norepinephrine transporter (NET) and serotonin transporter (SERT) inhibitor. Desmethyl Sibutramine hydrochloride can be used in the research of obesity and appetite suppressant[1][2][3][4].
Related Catalog	Research Areas >> Metabolic Disease Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> Serotonin Transporter
Target	NET and SERT[1]
References	[1]. Talbot PS, et, al. Brain serotonin transporter occupancy by oral sibutramine dosed to steady state: a PET study using (11)C-DASB in healthy humans. Neuropsychopharmacology. 2010 Feb;35(3):741-51. [2]. Luscombe GP, et, al. The contribution of metabolites to the rapid and potent down-regulation of rat cortical beta-adrenoceptors by the putative antidepressant sibutramine hydrochloride. Neuropharmacology. 1989 Feb;28(2):129-34. [3]. Wang J, et, al. Analysis of six synthetic adulterants in herbal weight-reducing dietary supplements by LC electrospray ionization-MS. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008 Jul;25(7):822-30. [4]. Ponnuru VS, et, al. Quantification of sibutramine and its two metabolites in human plasma by LC-ESI-MS/MS and its application in a bioequivalence study. J Pharm Anal. 2012 Aug;2(4):249-257.

RIDADR	NONH for all modes of transport