Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1,4-Pentanediamine,N4-(7-chloro-4-quinolinyl)-N1-ethyl-
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1476-52-4

1476-52-4 structure

Name: Desethyl Chloroquine
Chemical Name: Desethyl Chloroquine
CAS Number: 1476-52-4
Molecular Formula: C₁₆H₂₂ClN₃
Molecular Weight: 291.81900
Catalog: analytical chemistry Standard Pharmacopoeia Standards and Magazine Standards
Create Date: 2019-02-05 17:40:41
Modify Date: 2026-07-07 15:20:34
Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity[1][2].

Name	Desethyl Chloroquine
Synonyms	Hydroxychloroquine Sulfate Impurity D (Chloroquine Related Compound D, Desethyl Chloroquine) Hydroxychloroquine Impurity 9 2HBr 4-N-(7-chloroquinolin-4-yl)-1-N-ethylpentane-1,4-diamine 4-[[1-Methyl-4-(ethylamino)butyl]amino]-7-chloroquinoline N4-(7-chloroquinolin-4-yl)-N1-ethyl-pentane-1,4-diamine Desethyl Chloroquine HBr (Hydroxychloroquine Sulfate Impurity D HBr) Chloroquine Related Compound-D Chloroquine RC D N4-(7-Chloro-4-quinolinyl)-N1-ethyl-1,4-pentanediamine 7-Chloro-4-{[4-(ethylamino)-1-methylbutyl]amino}quinoline,Monodesethylchloroquine N'-(7-Chloroquinolin-4-yl)-N-ethyl-1,4-pentanediamine DESETHYL CHLOROQUINE Chloroquine Impurity 1（Desethyl Chloroquine） Hydroxychloroquine Sulfate Impurity D DiHBr 7-Chloro-4-{[4-(ethylamino)-1-methylbutyl]amino}quinoline (4RS)-N4-(7-Chloroquinolin-4-yl)-N1-ethylpentane-1,4-diamine 1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1-ethyl N-[4-(Ethylamino)-1-methylbutyl]-7-chloroquinoline-4-amine Hydroxychloroquine Sulfate Impurity 4（Hydroxychloroquine Sulfate Impurity D） Monodeethylchloroquine Chloroquine Related Compound D Desethyl Chloroquine sulfate Chloroquine Related Compound D (7-Chloro-4-{[4-(ethylamino)-1-methylbutyl] amino} quinoline) Hydroxy Chloroquine Impurity-D Chloroquine Related CoMpound D Monodesethylchloroquine Clavulanate Potassium Impurity 20 Monomer Desethyl Chloroquine (Hydroxychloroquine Impurity D) Hydroxychloroquine Impurity D/Desethyl Chloroquine Deethylchloroquine N-[1-Methyl-4-(ethylamino)butyl]7-chloro-4-quinolinamine Desethyl Chloroquine DiHBr (Hydroxychloroquine Sulfate Impurity D DiHBr) Hydroxychloroquine Sulfate Impurity D (Desethyl Chloroquine) (7-chloro-4-quinolyl)-[4-(ethylamino)-1-methyl-butyl]amine

Description	Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR) Research Areas >> Infection Signaling Pathways >> Autophagy >> Autophagy
In Vitro	P. falciparum[1]
In Vivo	Intraperitoneal injections of Chloroquine are administered to wild-type and Huntington's disease (Q175/Q175) mice. LC-MS/MS is used to compare the levels Chloroquine and its metabolites in blood, brain and muscle tissue. Concentrations of Chloroquine are lower (5-15M), but more stable in brain tissue compared to blood or muscle between 4 and 24 hours after the last dose. Levels of the active Chloroquine metabolite Desethyl chloroquine decreased in muscle and blood over the 24 hour post-injection period, while brain Desethyl chloroquine levels are lower and rose slightly over the same time frame[3].
References	[1]. Ajayi FO, et al. Comparison of the partitioning in vitro of chloroquine and its desethyl metabolites between the erythrocytes and plasma of healthy subjects and those with falciparum malaria. Afr J Med Med Sci. 1989 Jun;18(2):95-100. [2]. Said A, et al. Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells. J Immunol. 2014 Dec 15;193(12):6135-43. [3]. Vodicka P, et al. Assessment of chloroquine treatment for modulating autophagy flux in brain of WT and HD mice. J Huntingtons Dis. 2014;3(2):159-74.

Density	1.138g/cm3
Boiling Point	451.7ºC at 760mmHg
Melting Point	94-97?C
Molecular Formula	C₁₆H₂₂ClN₃
Molecular Weight	291.81900
Flash Point	227ºC
Exact Mass	291.15000
PSA	36.95000
LogP	4.54220
Vapour Pressure	2.38E-08mmHg at 25°C
Index of Refraction	1.602
Storage condition	-20°C Freezer

RIDADR	NONH for all modes of transport
HS Code	2933499090

75-04-7

1476-52-4

Literature: Journal of the American Chemical Society, , vol. 68, p. 1224

54-05-7

1476-52-4

Literature: European Journal of Clinical Pharmacology, , vol. 59, # 5-6 p. 429 - 442

86-98-6

1476-52-4

Literature: Journal of the American Chemical Society, , vol. 68, p. 1224

Precursor 3
75-04-7 54-05-7 86-98-6
DownStream 0

HS Code	2933499090
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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