Desethyl Chloroquine
Modify Date: 2024-01-02 17:11:20
Desethyl Chloroquine structure
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Common Name | Desethyl Chloroquine | ||
|---|---|---|---|---|
| CAS Number | 1476-52-4 | Molecular Weight | 291.81900 | |
| Density | 1.138g/cm3 | Boiling Point | 451.7ºC at 760mmHg | |
| Molecular Formula | C16H22ClN3 | Melting Point | 94-97?C | |
| MSDS | N/A | Flash Point | 227ºC | |
Use of Desethyl ChloroquineDesethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity[1][2]. |
| Name | Desethyl Chloroquine |
|---|---|
| Synonym | More Synonyms |
| Description | Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity[1][2]. |
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| Related Catalog | |
| In Vitro | P. falciparum[1] |
| In Vivo | Intraperitoneal injections of Chloroquine are administered to wild-type and Huntington's disease (Q175/Q175) mice. LC-MS/MS is used to compare the levels Chloroquine and its metabolites in blood, brain and muscle tissue. Concentrations of Chloroquine are lower (5-15M), but more stable in brain tissue compared to blood or muscle between 4 and 24 hours after the last dose. Levels of the active Chloroquine metabolite Desethyl chloroquine decreased in muscle and blood over the 24 hour post-injection period, while brain Desethyl chloroquine levels are lower and rose slightly over the same time frame[3]. |
| References |
| Density | 1.138g/cm3 |
|---|---|
| Boiling Point | 451.7ºC at 760mmHg |
| Melting Point | 94-97?C |
| Molecular Formula | C16H22ClN3 |
| Molecular Weight | 291.81900 |
| Flash Point | 227ºC |
| Exact Mass | 291.15000 |
| PSA | 36.95000 |
| LogP | 4.54220 |
| Vapour Pressure | 2.38E-08mmHg at 25°C |
| Index of Refraction | 1.602 |
| Storage condition | -20°C Freezer |
| RIDADR | NONH for all modes of transport |
|---|---|
| HS Code | 2933499090 |
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Desethyl Chloroquine CAS#:1476-52-4 |
| Literature: Journal of the American Chemical Society, , vol. 68, p. 1224 |
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Desethyl Chloroquine CAS#:1476-52-4 |
| Literature: European Journal of Clinical Pharmacology, , vol. 59, # 5-6 p. 429 - 442 |
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Desethyl Chloroquine CAS#:1476-52-4 |
| Literature: Journal of the American Chemical Society, , vol. 68, p. 1224 |
| Precursor 3 | |
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| DownStream 0 | |
| HS Code | 2933499090 |
|---|---|
| Summary | 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Chloroquine Related Compound D |
| 4-N-(7-chloroquinolin-4-yl)-1-N-ethylpentane-1,4-diamine |
| 7-Chloro-4-{[4-(ethylamino)-1-methylbutyl]amino}quinoline,Monodesethylchloroquine |