104004-96-8

104004-96-8 structure

Name: N-Demethyl Mifepristone
Chemical Name: N-Demethyl Mifepristone
CAS Number: 104004-96-8
Molecular Formula: C₂₈H₃₃NO₂
Molecular Weight: 415.56700
Catalog: Signaling Pathways GPCR/G Protein Glucocorticoid Receptor
Create Date: 2018-05-10 08:00:00
Modify Date: 2024-01-11 17:38:11
N-Demethyl Mifepristone (RU 42633) is an active metabolite of Mifepristone (HY-13683). The affinities of N-Demethyl Mifepristone to the glucocorticoid receptor is 61% compared with 100% for Mifepristone[1].

Name	N-Demethyl Mifepristone
Synonyms	(8S,11R,13S,14S,17S)-17-hydroxy-13-methyl-11-[4-(methylamino)phenyl]-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one

Description	N-Demethyl Mifepristone (RU 42633) is an active metabolite of Mifepristone (HY-13683). The affinities of N-Demethyl Mifepristone to the glucocorticoid receptor is 61% compared with 100% for Mifepristone[1].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor
References	[1]. Nguyen D, et al. Effects of Ketoconazole on the Pharmacokinetics of Mifepristone, a Competitive Glucocorticoid Receptor Antagonist, in Healthy Men. Adv Ther. 2017 Oct;34(10):2371-2385.

Density	1.19g/cm3
Boiling Point	628.9ºC at 760mmHg
Molecular Formula	C₂₈H₃₃NO₂
Molecular Weight	415.56700
Flash Point	334.1ºC
Exact Mass	415.25100
PSA	49.33000
LogP	5.45520
Vapour Pressure	1.11E-16mmHg at 25°C
Index of Refraction	1.625

639520-83-5

~88%

104004-96-8

Literature: Von Geldern, Thomas W.; Tu, Noah; Kym, Philip R.; Link, James T.; Jae, Hwan-Soo; Lai, Chunqiu; Apelqvist, Theresa; Rhonnstad, Patrik; Hagberg, Lars; Koehler, Konrad; Grynfarb, Marlena; Goos-Nilsson, Annika; Sandberg, Johnny; Osterlund, Marie; Barkhem, Tomas; Hoeglund, Marie; Wang, Jiahong; Fung, Steven; Wilcox, Denise; Nguyen, Phong; Jakob, Clarissa; Hutchins, Charles; Faernegfardh, Mathias; Kauppi, Bjoern; Oehman, Lars; Jacobson, Peer B. Journal of Medicinal Chemistry, 2004 , vol. 47, # 17 p. 4213 - 4230

639520-75-5

~76%

104004-96-8

Literature: ABBOTT LABORATORIES Patent: WO2004/869 A1, 2003 ; Location in patent: Page 24; 27 ; WO 2004/000869 A1

84371-65-3

~80%

104004-96-8

Literature: Rao, Pemmaraju N.; Acosta, C. Kirk; Cessac, James W.; Bahr, Martin L.; Kim, Hyun K. Steroids, 1999 , vol. 64, # 3 p. 205 - 212

104004-98-0

~61%

104004-96-8

Literature: Mais; Chen; Wagoner; Scott Hayes; Wang Journal of Labelled Compounds and Radiopharmaceuticals, 1995 , vol. 36, # 12 p. 1199 - 1203

Precursor 4
639520-83-5 639520-75-5 84371-65-3 104004-98-0
DownStream 0

104004-96-8	1330173-19-7
992-62-1	32852-16-7
127140-69-6	38061-37-9
338992-12-4	40323-85-1
362044-01-7	859995-07-6