104004-96-8

• 常用中文名：N-去甲米非司酮
• 常用英文名：N-Demethyl Mifepristone
• CAS号：104004-96-8
• 分子式：C₂₈H₃₃NO₂
• 分子量：415.56700
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 糖皮质激素受体
• 发布时间：2018-05-10 08:00:00
• 更新时间：2026-08-06 18:25:01
• N-Demethyl Mifepristone (RU 42633) 是 Mifepristone (HY-13683) 的活性代谢物。N-Demethyl Mifepristone (RU 42633) 与 Mifepristone (100%) 相比对糖皮质激素受体 (glucocorticoid receptor) 的亲和力为 61%。

名称

• 中文名: N-去甲米非司酮
• 英文名: N-Demethyl Mifepristone
• 中文别名: N-脱甲基 - 米非司酮; 去甲米非司酮; 米非司酮杂质1; 米非司酮相关杂质; N-去甲基米非司酮 D3; N-去甲基米非司酮; 去甲基米非司酮
• 英文别名: Metapristone; Mifristone Impurity 1; N-DESMETHYL MIFRISTONE; (8S,11R,13S,14S,17S)-17-hydroxy-13-methyl-11-[4-(methylamino)phenyl]-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one; (8S,11R,13S)-17-hydroxy-13-methyl-11-(4-(methylamino)phenyl)-17-(prop-1-yn-1-yl)-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one; Estra-4,9-dien-3-one, 17-hydroxy-11-[4-(methylamino)phenyl]-17-(1-propyn-1-yl)-, (11β,17β); 11β-(p-Methylaminophenyl)-17β-hydroxy-17α-(1-propynyl)estra-4,9-diene-3-one; (11,17)-17-Hydroxy-11-[4-(methylamino)phenyl]-17-(1-propyn-1-yl)-estra-4,9-dien-3-one; N-Desmethyl Mifristone D3Q: What is N-Desmethyl Mifristone D3 Q: What is the CAS Number of N-Desmethyl Mifristone D3 Q: What is the storage condition of N-Desmethyl Mifristone D3 Q: What e the applications of N-Desmethyl Mifristone D3; N-Methylaminopristone; Desmethylmifristone; 11β-[4-(Methylamino)phenyl]-17β-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one; N-Desmethyl-RU; N-Demethyl Mifristone

物化性质

• 密度: 1.19g/cm3
• 沸点: 628.9ºC at 760mmHg
• 分子式: C₂₈H₃₃NO₂
• 分子量: 415.56700
• 闪点: 334.1ºC
• 精确质量: 415.25100
• PSA: 49.33000
• LogP: 5.45520
• 蒸汽压: 1.11E-16mmHg at 25°C
• 折射率: 1.625

生物活性

• 描述: N-Demethyl Mifepristone (RU 42633) 是 Mifepristone (HY-13683) 的活性代谢物。N-Demethyl Mifepristone (RU 42633) 与 Mifepristone (100%) 相比对糖皮质激素受体 (glucocorticoid receptor) 的亲和力为 61%。
• 相关类别:
  研究领域 >> 内分泌
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 糖皮质激素受体
• 参考文献:

  [1]. Nguyen D, et al. Effects of Ketoconazole on the Pharmacokinetics of Mifepristone, a Competitive Glucocorticoid Receptor Antagonist, in Healthy Men. Adv Ther. 2017 Oct;34(10):2371-2385.

合成路线

639520-83-5 ~88% 104004-96-8

文献：Von Geldern, Thomas W.; Tu, Noah; Kym, Philip R.; Link, James T.; Jae, Hwan-Soo; Lai, Chunqiu; Apelqvist, Theresa; Rhonnstad, Patrik; Hagberg, Lars; Koehler, Konrad; Grynfarb, Marlena; Goos-Nilsson, Annika; Sandberg, Johnny; Osterlund, Marie; Barkhem, Tomas; Hoeglund, Marie; Wang, Jiahong; Fung, Steven; Wilcox, Denise; Nguyen, Phong; Jakob, Clarissa; Hutchins, Charles; Faernegfardh, Mathias; Kauppi, Bjoern; Oehman, Lars; Jacobson, Peer B. Journal of Medicinal Chemistry, 2004 , vol. 47, # 17 p. 4213 - 4230

639520-75-5 ~76% 104004-96-8

文献：ABBOTT LABORATORIES Patent: WO2004/869 A1, 2003 ; Location in patent: Page 24; 27 ; WO 2004/000869 A1

84371-65-3 ~80% 104004-96-8

文献：Rao, Pemmaraju N.; Acosta, C. Kirk; Cessac, James W.; Bahr, Martin L.; Kim, Hyun K. Steroids, 1999 , vol. 64, # 3 p. 205 - 212

104004-98-0 ~61% 104004-96-8

文献：Mais; Chen; Wagoner; Scott Hayes; Wang Journal of Labelled Compounds and Radiopharmaceuticals, 1995 , vol. 36, # 12 p. 1199 - 1203

上下游产品

上游产品  4
639520-83-5 639520-75-5 84371-65-3 104004-98-0
下游产品  0