5428-80-8

5428-80-8 structure

Name: Vacquinol-1
Chemical Name: [2-(4-chlorophenyl)quinolin-4-yl]-piperidin-2-ylmethanol
CAS Number: 5428-80-8
Molecular Formula: C₂₁H₂₁ClN₂O
Molecular Weight: 352.857
Catalog: Research Areas Cancer
Create Date: 2016-03-02 06:25:12
Modify Date: 2025-08-29 11:08:43
Vacquinol-1 (NSC13316) is a MKK4-specific activator that activates MAPK pathways[1]. Vacquinol-1 specifically induces human glioblastoma cell (GC) death, attenuates tumor progression and prolongs survival in a glioblastoma multiforme (GBM) mouse model[2]. Vacquinol-1 also induces apoptosis in hepatocellular carcinoma (HCC)cell[3].

Name	[2-(4-chlorophenyl)quinolin-4-yl]-piperidin-2-ylmethanol
Synonyms	(2-(4-chlorophenyl)-4-quinolinyl)(2-piperidinyl)methanol 4-Quinolinemethanol, 2-(4-chlorophenyl)-α-2-piperidinyl- [2-(4-chlorophenyl)quinolin-4-yl](piperidin-2-yl)methanol [2-(4-chloro-phenyl)-[4]quinolyl]-[2]piperidyl-methanol [2-(4-Chlor-phenyl)-[4]chinolyl]-[2]piperidyl-methanol [2-(4-Chlorophenyl)-4-quinolinyl](2-piperidinyl)methanol Vacquinol-1

Description	Vacquinol-1 (NSC13316) is a MKK4-specific activator that activates MAPK pathways[1]. Vacquinol-1 specifically induces human glioblastoma cell (GC) death, attenuates tumor progression and prolongs survival in a glioblastoma multiforme (GBM) mouse model[2]. Vacquinol-1 also induces apoptosis in hepatocellular carcinoma (HCC)cell[3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Sun SL, Li X, Su N, et al. Vacquinol‑1 induces apoptosis in hepatocellular carcinoma cell. Mol Med Rep. 2018;18(1):557-563. [2]. Sander P, Mostafa H, Soboh A, et al. Vacquinol-1 inducible cell death in glioblastoma multiforme is counter regulated by TRPM7 activity induced by exogenous ATP. Oncotarget. 2017;8(21):35124-35137. [3]. Chao Wu, et al. Salvianolic acid B exerts anti-liver fibrosis effects via inhibition of MAPK-mediated phospho-Smad2/3 at linker regions in vivo and in vitro. Life Sci. 2019 Dec 15;239:116881. [4]. Yufeng Shi, et al. The soft underbelly of tumor cells. Cell Res. 2014 Aug;24(8):910-1. [5]. Shu-Lan Sun, et al. Vacquinol 1 induces apoptosis in hepatocellular carcinoma cell. Mol Med Rep. 2018 Jul;18(1):557-563.

HS Code	2933990090

854864-03-2

5428-80-8

Literature: Brown et al. Journal of the American Chemical Society, 1946 , vol. 68, p. 2705,2707

7147-98-0

198705-39-4

5428-80-8

Literature: Brown et al. Journal of the American Chemical Society, 1946 , vol. 68, p. 2705,2707

Precursor 2
854864-03-2 7147-98-0
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%