Vacquinol-1

Modify Date: 2025-08-29 11:08:43

Vacquinol-1 structure	Common Name	Vacquinol-1
	CAS Number	5428-80-8	Molecular Weight	352.857
	Density	1.2±0.1 g/cm3	Boiling Point	551.4±50.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₂₁ClN₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	287.3±30.1 °C

Use of Vacquinol-1

Vacquinol-1 (NSC13316) is a MKK4-specific activator that activates MAPK pathways[1]. Vacquinol-1 specifically induces human glioblastoma cell (GC) death, attenuates tumor progression and prolongs survival in a glioblastoma multiforme (GBM) mouse model[2]. Vacquinol-1 also induces apoptosis in hepatocellular carcinoma (HCC)cell[3].

Name	[2-(4-chlorophenyl)quinolin-4-yl]-piperidin-2-ylmethanol
Synonym	More Synonyms

Description	Vacquinol-1 (NSC13316) is a MKK4-specific activator that activates MAPK pathways[1]. Vacquinol-1 specifically induces human glioblastoma cell (GC) death, attenuates tumor progression and prolongs survival in a glioblastoma multiforme (GBM) mouse model[2]. Vacquinol-1 also induces apoptosis in hepatocellular carcinoma (HCC)cell[3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Sun SL, Li X, Su N, et al. Vacquinol‑1 induces apoptosis in hepatocellular carcinoma cell. Mol Med Rep. 2018;18(1):557-563. [2]. Sander P, Mostafa H, Soboh A, et al. Vacquinol-1 inducible cell death in glioblastoma multiforme is counter regulated by TRPM7 activity induced by exogenous ATP. Oncotarget. 2017;8(21):35124-35137. [3]. Chao Wu, et al. Salvianolic acid B exerts anti-liver fibrosis effects via inhibition of MAPK-mediated phospho-Smad2/3 at linker regions in vivo and in vitro. Life Sci. 2019 Dec 15;239:116881. [4]. Yufeng Shi, et al. The soft underbelly of tumor cells. Cell Res. 2014 Aug;24(8):910-1. [5]. Shu-Lan Sun, et al. Vacquinol 1 induces apoptosis in hepatocellular carcinoma cell. Mol Med Rep. 2018 Jul;18(1):557-563.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

References

[1]. Sun SL, Li X, Su N, et al. Vacquinol‑1 induces apoptosis in hepatocellular carcinoma cell. Mol Med Rep. 2018;18(1):557-563.

[2]. Sander P, Mostafa H, Soboh A, et al. Vacquinol-1 inducible cell death in glioblastoma multiforme is counter regulated by TRPM7 activity induced by exogenous ATP. Oncotarget. 2017;8(21):35124-35137.

[3]. Chao Wu, et al. Salvianolic acid B exerts anti-liver fibrosis effects via inhibition of MAPK-mediated phospho-Smad2/3 at linker regions in vivo and in vitro. Life Sci. 2019 Dec 15;239:116881.

[4]. Yufeng Shi, et al. The soft underbelly of tumor cells. Cell Res. 2014 Aug;24(8):910-1.

[5]. Shu-Lan Sun, et al. Vacquinol 1 induces apoptosis in hepatocellular carcinoma cell. Mol Med Rep. 2018 Jul;18(1):557-563.

Density	1.2±0.1 g/cm3
Boiling Point	551.4±50.0 °C at 760 mmHg
Molecular Formula	C₂₁H₂₁ClN₂O
Molecular Weight	352.857
Flash Point	287.3±30.1 °C
Exact Mass	352.134247
PSA	45.15000
LogP	3.87
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.643
Storage condition	-20℃

HS Code	2933990090

2-(4-chloro-phe...

CAS#:854864-03-2

Vacquinol-1

CAS#:5428-80-8

Literature: Brown et al. Journal of the American Chemical Society, 1946 , vol. 68, p. 2705,2707

4-Quinolinecarb...

CAS#:7147-98-0

N/A

CAS#:198705-39-4

Vacquinol-1

CAS#:5428-80-8

Literature: Brown et al. Journal of the American Chemical Society, 1946 , vol. 68, p. 2705,2707

Precursor 2
CAS#:854864-03-2 2-(4-chloro-phe... CAS#:7147-98-0 4-Quinolinecarb...
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

(2-(4-chlorophenyl)-4-quinolinyl)(2-piperidinyl)methanol

4-Quinolinemethanol, 2-(4-chlorophenyl)-α-2-piperidinyl-

[2-(4-chlorophenyl)quinolin-4-yl](piperidin-2-yl)methanol

[2-(4-chloro-phenyl)-[4]quinolyl]-[2]piperidyl-methanol

[2-(4-Chlor-phenyl)-[4]chinolyl]-[2]piperidyl-methanol

[2-(4-Chlorophenyl)-4-quinolinyl](2-piperidinyl)methanol

Vacquinol-1

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Vacquinol-1

Use of Vacquinol-1

Names

Vacquinol-1 Biological Activity

Chemical & Physical Properties

Safety Information

Synthetic Route

Precursor & DownStream

Customs

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.