Vacquinol-1
Modify Date: 2024-01-05 17:51:37
Vacquinol-1 structure
|
Common Name | Vacquinol-1 | ||
|---|---|---|---|---|
| CAS Number | 5428-80-8 | Molecular Weight | 352.857 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 551.4±50.0 °C at 760 mmHg | |
| Molecular Formula | C21H21ClN2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 287.3±30.1 °C | |
Use of Vacquinol-1Vacquinol-1 (NSC13316) is a MKK4-specific activator that activates MAPK pathways[1]. Vacquinol-1 specifically induces human glioblastoma cell (GC) death, attenuates tumor progression and prolongs survival in a glioblastoma multiforme (GBM) mouse model[2]. Vacquinol-1 also induces apoptosis in hepatocellular carcinoma (HCC)cell[3]. |
| Name | [2-(4-chlorophenyl)quinolin-4-yl]-piperidin-2-ylmethanol |
|---|---|
| Synonym | More Synonyms |
| Description | Vacquinol-1 (NSC13316) is a MKK4-specific activator that activates MAPK pathways[1]. Vacquinol-1 specifically induces human glioblastoma cell (GC) death, attenuates tumor progression and prolongs survival in a glioblastoma multiforme (GBM) mouse model[2]. Vacquinol-1 also induces apoptosis in hepatocellular carcinoma (HCC)cell[3]. |
|---|---|
| Related Catalog | |
| References |
[4]. Yufeng Shi, et al. The soft underbelly of tumor cells. Cell Res. 2014 Aug;24(8):910-1. |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 551.4±50.0 °C at 760 mmHg |
| Molecular Formula | C21H21ClN2O |
| Molecular Weight | 352.857 |
| Flash Point | 287.3±30.1 °C |
| Exact Mass | 352.134247 |
| PSA | 45.15000 |
| LogP | 3.87 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.643 |
| Storage condition | -20℃ |
| HS Code | 2933990090 |
|---|
|
~%
Vacquinol-1 CAS#:5428-80-8 |
| Literature: Brown et al. Journal of the American Chemical Society, 1946 , vol. 68, p. 2705,2707 |
|
~%
Vacquinol-1 CAS#:5428-80-8 |
| Literature: Brown et al. Journal of the American Chemical Society, 1946 , vol. 68, p. 2705,2707 |
| Precursor 2 | |
|---|---|
| DownStream 0 | |
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| (2-(4-chlorophenyl)-4-quinolinyl)(2-piperidinyl)methanol |
| 4-Quinolinemethanol, 2-(4-chlorophenyl)-α-2-piperidinyl- |
| [2-(4-chlorophenyl)quinolin-4-yl](piperidin-2-yl)methanol |
| [2-(4-chloro-phenyl)-[4]quinolyl]-[2]piperidyl-methanol |
| [2-(4-Chlor-phenyl)-[4]chinolyl]-[2]piperidyl-methanol |
| [2-(4-Chlorophenyl)-4-quinolinyl](2-piperidinyl)methanol |
| Vacquinol-1 |