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924296-18-4

924296-18-4 structure
924296-18-4 structure
  • Name: DUBs-IN-1
  • Chemical Name: 9-[(Benzyloxy)imino]-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile
  • CAS Number: 924296-18-4
  • Molecular Formula: C20H11N5O
  • Molecular Weight: 337.33400
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage Deubiquitinase
  • Create Date: 2018-12-28 15:17:58
  • Modify Date: 2025-08-27 00:04:21
  • DUBs-IN-1 is an active inhibitor of ubiquitin-specific proteases (USPs), with an IC50 of 0.24 μM for USP8.

Name 9-[(Benzyloxy)imino]-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile
Synonyms DUBs-IN-1
Description DUBs-IN-1 is an active inhibitor of ubiquitin-specific proteases (USPs), with an IC50 of 0.24 μM for USP8.
Related Catalog
Target

IC50: 0.24 μM (USP8)[1]

In Vitro DUBs-IN-1 (22 f) is an active inhibitor of ubiquitin-specific proteases, with an IC50 of 0.24 μM for USP8. DUBs-IN-1 is inactive toward USP7 (IC50, >100 μM). DUBs-IN-1 and its analogs reduce the viability of HCT116 colon and PC-3 prostate cancer cell lines with IC50s ranging from 0.5 μM to 1.5 μM[1].
References

[1]. Colombo M, et al. Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem. 2010 Apr 6;5(4):552-8.

Density 1.32g/cm3
Boiling Point 632.2ºC at 760 mmHg
Molecular Formula C20H11N5O
Molecular Weight 337.33400
Flash Point 336.2ºC
Exact Mass 337.09600
PSA 94.95000
LogP 3.16956
Index of Refraction 1.704
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