862907-48-0

862907-48-0 structure

Name: AH-3960
Chemical Name: 1,3-Dibutyl-5-(diaminomethylene)-2,4,6(1H,3H,5H)-pyrimidinetrione
CAS Number: 862907-48-0
Molecular Formula: C₁₃H₂₂N₄O₃
Molecular Weight: 282.33900
Catalog: Research Areas Cancer
Create Date: 2017-08-15 10:20:10
Modify Date: 2024-01-31 11:58:55
AH3960 (compound 16c) is an antagonist of androgen receptor. AH3960 binds wild as well as T877 mutant type androgen receptors. AH3960 selectively inhibits T877 with an IC50 value of 0.82 μM. AH3960 also serves as an agonist of parathyroid hormone receptor-1 (PTHR1)[1][2].

Name	1,3-Dibutyl-5-(diaminomethylene)-2,4,6(1H,3H,5H)-pyrimidinetrione
Synonyms	AH-3960

Description	AH3960 (compound 16c) is an antagonist of androgen receptor. AH3960 binds wild as well as T877 mutant type androgen receptors. AH3960 selectively inhibits T877 with an IC50 value of 0.82 μM. AH3960 also serves as an agonist of parathyroid hormone receptor-1 (PTHR1)[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Thyroid Hormone Receptor Signaling Pathways >> Others >> Androgen Receptor
References	[1]. Yamamoto S, et al. Design, synthesis, and biological evaluation of 4-arylmethyl-1-phenylpyrazole and 4-aryloxy-1-phenylpyrazole derivatives as novel androgen receptor antagonists. Bioorg Med Chem. 2012 Apr 1;20(7):2338-52. [2]. Carter PH, et al. Actions of the small molecule ligands SW106 and AH-3960 on the type-1 parathyroid hormone receptor. Mol Endocrinol. 2015 Feb;29(2):307-21.