110429-45-3
110429-45-3 structure
- Name: m-PEG4-Br
- Chemical Name: Triethylene Glycol 2-Bromoethyl Methyl Ether
- CAS Number: 110429-45-3
- Molecular Formula: C9H19BrO4
- Molecular Weight: 271.14900
- Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
- Create Date: 2018-12-08 17:54:55
- Modify Date: 2024-01-05 20:08:27
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m-PEG4-Br is a cleavable ADC linker used in the synthesis of antibody-drug conjugate (ADC) for Trastuzumab (HY-P9907). m-PEG4-Br is placed distally from the monomethyl auristatin E (MMAE) payload to yield an ADC with altered hydrophilicity, antigen binding, and in vitro potency[1].
| Name | Triethylene Glycol 2-Bromoethyl Methyl Ether |
|---|---|
| Synonyms |
1-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]-2-methoxyethane
Triethylene Glycol 2-BroMoethyl Methyl Ether 2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethyl Bromide 1-Bromo-3,6,9,12-tetraoxatridecane |
| Description | m-PEG4-Br is a cleavable ADC linker used in the synthesis of antibody-drug conjugate (ADC) for Trastuzumab (HY-P9907). m-PEG4-Br is placed distally from the monomethyl auristatin E (MMAE) payload to yield an ADC with altered hydrophilicity, antigen binding, and in vitro potency[1]. |
|---|---|
| Related Catalog | |
| Target |
Cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
| References |
| Density | 1.256g/cm3 |
|---|---|
| Boiling Point | 296.3ºC at 760 mmHg |
| Molecular Formula | C9H19BrO4 |
| Molecular Weight | 271.14900 |
| Flash Point | 118.8ºC |
| Exact Mass | 270.04700 |
| PSA | 36.92000 |
| LogP | 1.07750 |
| Vapour Pressure | 0.00256mmHg at 25°C |
| Index of Refraction | 1.454 |
| Storage condition | 2-8°C |