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117235-10-6

117235-10-6 structure
117235-10-6 structure
  • Name: 3-Mercaptopropionic acid NHS ester
  • Chemical Name: (2,5-dioxopyrrolidin-1-yl) 3-sulfanylpropanoate
  • CAS Number: 117235-10-6
  • Molecular Formula: C7H9NO4S
  • Molecular Weight: 203.21600
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2017-08-17 04:04:03
  • Modify Date: 2025-08-28 12:13:41
  • 3-Mercaptopropanyl-N-hydroxysuccinimide ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name (2,5-dioxopyrrolidin-1-yl) 3-sulfanylpropanoate
Synonyms 3-Mercapropropanoyl-N-hydroxysuccinimide ester
1-(3-mercapto-1-oxopropoxy)-2,5-pyrrolidinedione
Description 3-Mercaptopropanyl-N-hydroxysuccinimide ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Density 1.40±0.1 g/cm3
Boiling Point 318.4±44.0 °C
Molecular Formula C7H9NO4S
Molecular Weight 203.21600
Exact Mass 203.02500
PSA 102.48000
Hazard Codes Xi
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