153436-38-5

153436-38-5 structure

Name: Gavestinel
Chemical Name: sodium,3-[(E)-3-anilino-3-oxoprop-1-enyl]-4,6-dichloro-1H-indole-2-carboxylate
CAS Number: 153436-38-5
Molecular Formula: C₁₈H₁₁Cl₂N₂NaO₃
Molecular Weight: 397.19
Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
Create Date: 2016-04-10 06:44:51
Modify Date: 2024-01-10 11:54:40
Gavestinel (GV 150526) is a potent, selective, orally active and non-competitive antagonist of NMDA receptor. Gavestinel binds to the glycine site of the NMDA receptor, with a pKi of 8.5. Gavestinel can be used for the research of acute ischemic stroke[1].

Name	sodium,3-[(E)-3-anilino-3-oxoprop-1-enyl]-4,6-dichloro-1H-indole-2-carboxylate
Synonyms	UNII-80W7787JVB 4,6-dichloro-3-((1E)-3-oxo-3-(phenylamino)-1-propenyl)-1H-indole-2-carboxylic acid sodium salt Gavestinel sodium

Description	Gavestinel (GV 150526) is a potent, selective, orally active and non-competitive antagonist of NMDA receptor. Gavestinel binds to the glycine site of the NMDA receptor, with a pKi of 8.5. Gavestinel can be used for the research of acute ischemic stroke[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Cardiovascular Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
Target	pKi: 8.5 (NMDA receptor)[1]
References	[1]. Fabio RD, et, al. Substituted indole-2-carboxylates as in vivo potent antagonists acting as the strychnine-insensitive glycine binding site. J Med Chem. 1997 Mar 14;40(6):841-50.