1404-90-6
1404-90-6 structure
- Name: Vancomycin
- Chemical Name: Vancomycin
- CAS Number: 1404-90-6
- Molecular Formula: C66H75Cl2N9O24
- Molecular Weight: 1449.25
- Catalog: API Antibiotics Peptide
- Create Date: 2018-08-04 23:12:46
- Modify Date: 2026-06-30 11:13:45
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Vancomycin is an antibiotic for the treatment of bacterial infections.
| Name | Vancomycin |
|---|---|
| Synonyms |
(3S,6R,7R,22R,23S,26S,36R,38-3-(2-Amino-2-oxoethyl)-44-[[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-α-L-lyxo-hexopyranosyl)-β-D-glucopyranosyl]oxy]-10,19-dichloro-2,3,4,5,6,7,23,24,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-[[(2R)-4-methyl-2-(methylamino)-1-oxopentyl]amino]-2,5,24,38,39-pentaoxo-22H-8,11:18,21-Dietheno-23,36-(iminomethano)-13,16:31,35-dimetheno-1H,16H-[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-cboxylic acid
Vancomycin Base Vancomycin (base and/or unspecified salts) vancomycin hcl vancocin MFCD05664587 EINECS 215-772-6 Vancomycin Impurity 21 demethylvancomycin //BP (1S,2R,18R,22S,25R,28R,40R)-48-{[(2S,3R,4S,5S,6R)-3-{[(2S,4S,5S,6S)-4-amino-5-hydroxy-4,6-dimethyloxan-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-22-(cbamoylmethyl)-5,47-dichloro-2,18,32,35,37-pentahydroxy-19-[(2R)-4-methyl-2-(methylamino)pentanamido]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2^{3,6}.2^{14,17}.1^{8,12}.1^{29,33}.0^{10,25}.0^{34,39}]pentaconta-3,5,8,9,11,14,16,29,30,32,34,36,38,46,49-pentadecaene-40-cboxylic acid VANCOMYCIN (3S,6R,7R,22R,23S,26S,36R,38-3-(2-Amino-2-oxoethyl)-44-[[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-α-L-lyxo-hexopyranosyl)-β-D-glucopyranosyl]oxy]-10,19-dichloro-2,3,4,5,6,7,23,24,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-[[(2R)-4-met (1S,2R,18R,19R,22S,25R,28R,40S)-22-(2-Amino-2-oxoethyl)-48-{[(5ξ)-2-O-(3-amino-2,3,6-trideoxy-3-methyl-α-L-lyxo-hexopyranosyl)-β-D-xylo-hexopyranosyl]oxy}-5,15-dichloro-2,18,32,35,37-pentahydr oxy-19-[(N-methyl-D-leucyl)amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2.2.1.1.0.0]pentaconta-3,5,8(48),9,11,14,16,29(45), 30,32,34,36,38,46,49-pentadecaene-40-carboxy Vancomycin,，≥950μg/mg Vancomycin //BP Vancomycin D12 Vancomycin D13 Vancomycin D10 Vancomycin solution (10mg/ml) Vancomycin alkaloids Vancomycin Monomer |
| Description | Vancomycin is an antibiotic for the treatment of bacterial infections. |
|---|---|
| Related Catalog | |
| In Vitro | Vancomycin is a large glycopeptide compound with a molecular weight of 1450 Da[1]. Vancomycin is a unique glycopeptide structurally unrelated to any currently available antibiotic. It also has a unique mode of action inhibiting the second stage of cell wall synthesis of susceptible bacteria. Vancomycin is active against a large number of species of Gram-positive bacteria, such as Staphylococcus aureus, Staph. epidermidis, Str. agalactiae, Str. bovis, Str. mutans, viridans streptococci, enterococci[2]. |
| In Vivo | Vancomycin is administered intravenously, with a standard infusion time of at least 1 h, to minimize infusion-related adverse effects. Subjects with normal creatinine clearance, vancomycin has an α-distribution phase of 30 min to 1 h and a β-elimination half-life of 6-12 h. The volume of distribution is 0.4–1 L/kg. The binding of vancomycin to protein ranges from 10% to 50%. Factors that affect the overall activity of vancomycin include its tissue distribution, inoculum size, and protein-binding effects[1]. Vancomycin treatment of infected mice is associated with improved clinical, diarrhea, and histopathology scores and survival during treatment[3]. |
| Animal Admin | Mice: One set of experiments is performed in which infected mice are treated with vancomycin (50 mg/kg) daily for 1, 2, 3, or 5 days and are observed for 21 days postinfection or with vancomycin (20 mg/kg) daily for either 5 or 10 days and monitoring for 15 days postinfection[3]. |
| References |
| Density | 1.65 g/cm3 |
|---|---|
| Molecular Formula | C66H75Cl2N9O24 |
| Molecular Weight | 1449.25 |
| PSA | 530.49000 |
| LogP | 4.73460 |
| Storage condition | -20℃ |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| HS Code | 3004209090 |
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~%
1404-90-6 |
| Literature: Journal of the American Chemical Society, , vol. 127, # 30 p. 10747 - 10752 |
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~79%
1404-90-6 |
| Literature: Thompson, Christopher; Ge, Min; Kahne, Daniel Journal of the American Chemical Society, 1999 , vol. 121, # 6 p. 1237 - 1244 |
| Precursor 1 | |
|---|---|
| DownStream 0 | |
| HS Code | 3004209090 |
|---|