98991-32-3
98991-32-3 structure
- Name: 4-FLUORO-4'-BROMOCHALCONE
- Chemical Name: 1-(4-bromophenyl)-3-(4-fluorophenyl)prop-2-en-1-one
- CAS Number: 98991-32-3
- Molecular Formula: C15H10BrFO
- Molecular Weight: 305.14
- Catalog: Signaling Pathways Neuronal Signaling Monoamine Oxidase
- Create Date: 2016-01-15 10:21:56
- Modify Date: 2025-08-25 17:10:38
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CHBO4 is a potent, reversible, competitive, and selective hMAO-B inhibitor with an IC50 value of 0.031 μM in CHBO subseries and an Ki value of 0.010 ± 0.005 μM. CHBO4 reduce cell damage by scavenging intracellular reactive oxygen species (ROS). CHBO4 can be used for Parkinson's Disease (PD) research[1].
| Name | 1-(4-bromophenyl)-3-(4-fluorophenyl)prop-2-en-1-one |
|---|---|
| Synonyms |
2-Propen-1-one,1-(4-bromophenyl)-3-(4-fluorophenyl)
4-Fluoro-4'-bromochalcone |
| Description | CHBO4 is a potent, reversible, competitive, and selective hMAO-B inhibitor with an IC50 value of 0.031 μM in CHBO subseries and an Ki value of 0.010 ± 0.005 μM. CHBO4 reduce cell damage by scavenging intracellular reactive oxygen species (ROS). CHBO4 can be used for Parkinson's Disease (PD) research[1]. |
|---|---|
| Related Catalog | |
| Target |
hMAO-B:0.031 μM (IC50) hMAO-B:0.010 μM (Ki) |
| References |
| Molecular Formula | C15H10BrFO |
|---|---|
| Molecular Weight | 305.14 |
| Exact Mass | 303.99000 |
| PSA | 17.07000 |
| LogP | 4.48430 |
|
~98%
98991-32-3 |
| Literature: Tiwari, Urvashi; Ameta, Chetna; Rawal, Manish K.; Ameta, Rakshit; Punjabi, Pinki B. Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2013 , vol. 52, # 3 p. 432 - 439 |
|
~18%
98991-32-3
Detail
|
| Literature: El-Bayouki; Basyouni; El-Sayed; Tohamy; El-Henawy Croatica Chemica Acta, 2012 , vol. 85, # 3 p. 255 - 268 |
|
~18%
98991-32-3
Detail
|
| Literature: El-Bayouki; Basyouni; El-Sayed; Tohamy; El-Henawy Croatica Chemica Acta, 2012 , vol. 85, # 3 p. 255 - 268 |
