4-FLUORO-4'-BROMOCHALCONE

Modify Date: 2024-01-13 16:39:03

4-FLUORO-4'-BROMOCHALCONE Structure
4-FLUORO-4'-BROMOCHALCONE structure
Common Name 4-FLUORO-4'-BROMOCHALCONE
CAS Number 98991-32-3 Molecular Weight 305.14
Density N/A Boiling Point N/A
Molecular Formula C15H10BrFO Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 4-FLUORO-4'-BROMOCHALCONE


CHBO4 is a potent, reversible, competitive, and selective hMAO-B inhibitor with an IC50 value of 0.031 μM in CHBO subseries and an Ki value of 0.010 ± 0.005 μM. CHBO4 reduce cell damage by scavenging intracellular reactive oxygen species (ROS). CHBO4 can be used for Parkinson's Disease (PD) research[1].

 Names

Name 1-(4-bromophenyl)-3-(4-fluorophenyl)prop-2-en-1-one
Synonym More Synonyms

 4-FLUORO-4'-BROMOCHALCONE Biological Activity

Description CHBO4 is a potent, reversible, competitive, and selective hMAO-B inhibitor with an IC50 value of 0.031 μM in CHBO subseries and an Ki value of 0.010 ± 0.005 μM. CHBO4 reduce cell damage by scavenging intracellular reactive oxygen species (ROS). CHBO4 can be used for Parkinson's Disease (PD) research[1].
Related Catalog
Target

hMAO-B:0.031 μM (IC50)

hMAO-B:0.010 μM (Ki)

References

[1]. Thomas Parambi DG, et al. Halogenated class of oximes as a new class of monoamine oxidase-B inhibitors for the treatment of Parkinson's disease: Synthesis, biochemistry, and molecular dynamics study. Comput Biol Chem. 2023 Aug;105:107899.  

 Chemical & Physical Properties

Molecular Formula C15H10BrFO
Molecular Weight 305.14
Exact Mass 303.99000
PSA 17.07000
LogP 4.48430

 Synthetic Route

~98%

4-FLUORO-4'-BROMOCHALCONE Structure

4-FLUORO-4'-BRO...

CAS#:98991-32-3

Literature: Tiwari, Urvashi; Ameta, Chetna; Rawal, Manish K.; Ameta, Rakshit; Punjabi, Pinki B. Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2013 , vol. 52, # 3 p. 432 - 439

~18%

4-FLUORO-4'-BROMOCHALCONE Structure

4-FLUORO-4'-BRO...

CAS#:98991-32-3

Detail
Literature: El-Bayouki; Basyouni; El-Sayed; Tohamy; El-Henawy Croatica Chemica Acta, 2012 , vol. 85, # 3 p. 255 - 268

~18%

4-FLUORO-4'-BROMOCHALCONE Structure

4-FLUORO-4'-BRO...

CAS#:98991-32-3

Detail
Literature: El-Bayouki; Basyouni; El-Sayed; Tohamy; El-Henawy Croatica Chemica Acta, 2012 , vol. 85, # 3 p. 255 - 268

 Synonyms

2-Propen-1-one,1-(4-bromophenyl)-3-(4-fluorophenyl)
4-Fluoro-4'-bromochalcone
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