374620-70-9

374620-70-9 structure

Name: NBI 31772
Chemical Name: 1-[(3,4-dioxocyclohexa-1,5-dien-1-yl)-hydroxymethylidene]-6,7-dihydroxy-2H-isoquinoline-3-carboxylic acid
CAS Number: 374620-70-9
Molecular Formula: C₁₇H₁₁NO₇
Molecular Weight: 341.27200
Create Date: 2017-12-07 11:43:04
Modify Date: 2025-08-25 15:02:23
NBI-31772 is the potent and nonselective inhibitor of IGFBP with a Ki value of 47 nM. NBI-31772 has the potential for the research of IGF-responsive diseases[1].

Name	1-[(3,4-dioxocyclohexa-1,5-dien-1-yl)-hydroxymethylidene]-6,7-dihydroxy-2H-isoquinoline-3-carboxylic acid
Synonyms	3-Isoquinolinecarboxylic acid,1-(3,4-dihydroxybenzoyl)-6,7-dihydroxy

Description	NBI-31772 is the potent and nonselective inhibitor of IGFBP with a Ki value of 47 nM. NBI-31772 has the potential for the research of IGF-responsive diseases[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IGF-1R
References	[1]. Khawaja XZ. Development of a scintillation proximity assay for human insulin-like growth factor-binding protein 4 compatible with inhibitor high-throughput screening. Anal Biochem. 2007;366(1):80-86.