149404-21-7

149404-21-7 structure

Name: sodium,(2S)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]pyrrolidine-2-carboxylate
Chemical Name: sodium,(2S)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]pyrrolidine-2-carboxylate
CAS Number: 149404-21-7
Molecular Formula: C₂₀H₂₇N₂NaO₅
Molecular Weight: 398.42900
Catalog: Signaling Pathways Metabolic Enzyme/Protease Angiotensin-converting Enzyme (ACE)
Create Date: 2017-06-23 21:09:27
Modify Date: 2024-04-13 14:46:09
Enalapril (MK-421) sodium is an angiotensin-converting enzyme (ACE) inhibitor, can be used for hypertensive diseases research[1][2].

Name	sodium,(2S)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]pyrrolidine-2-carboxylate
Synonyms	unii-94a7ufl2si

Description	Enalapril (MK-421) sodium is an angiotensin-converting enzyme (ACE) inhibitor, can be used for hypertensive diseases research[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)
In Vitro	Enalapril sodium (10-20 μM) has an antiarrhythmic effect in ultrafiltered PV sleeve preparation isolated from canine hearts which can inhibit EAD and DAD-induced activity[1]. Enalapril sodium (50 μM, 24 hours) inhibits the induction of apoptosis by patient serum only when used prior to treatment of HUVEC with Alzheimer's disease (AD) serum[2]. Pure Enalapril sodium has better thermal stability than pure Enalapril[3]. Apoptosis Analysis[2] Cell Line: Human umbilical vein ECs (HUVECs) Concentration: 50 μM Incubation Time: 24 hours Result: Inhibited the induction of apoptosis by patient serum.
In Vivo	Enalapril sodium (intraperitoneal injection, 0.03 mg/kg, once, 1 hour) reduces infarct volume due to middle cerebral artery occlusion and lower or higher doses are ineffective in Male NMRI mice[4]. Animal Model: Male NMRI mice 20-40 g[4] Dosage: 0.03 mg/kg Administration: Intraperitoneal injection; once; 1 hour Result: Reduced the area of middle cerebral artery infarction in mice at 0.03 mg/kg.
References	[1]. Serge Sicouri, et al. Antiarrhythmic effects of losartan and enalapril in canine pulmonary vein sleeve preparations. J Cardiovasc Electrophysiol. 2011 Jun;22(6):698-705. [2]. Rokhsareh Meamar, et al. Enalapril protects endothelial cells against induced apoptosis in Alzheimer's disease. J Res Med Sci. 2013 Mar;18(Suppl 1):S1-5. [3]. Talita A Cunha, et al. Effect of stearic acid on enalapril stability and dissolution from multiparticulate solid dosage forms. AAPS PharmSciTech. 2013 Sep;14(3):1150-7. [4]. A Ravati, et al. Enalapril and moexipril protect from free radical-induced neuronal damage in vitro and reduce ischemic brain injury in mice and rats. Eur J Pharmacol. 1999 May 28;373(1):21-33.

Molecular Formula	C₂₀H₂₇N₂NaO₅
Molecular Weight	398.42900
Exact Mass	398.18200
PSA	98.77000
LogP	0.59870

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

1396686-20-6	1396784-81-8
1396857-38-7	1396843-62-1
1421484-03-8	1396843-77-8
1396800-66-0	2377607-40-2
1396784-99-8	1396881-24-5