1141934-97-5

1141934-97-5 structure

Name: Emixustat (hydrochloride)
Chemical Name: (1R)-3-amino-1-[3-(cyclohexylmethoxy)phenyl]propan-1-ol,hydrochloride
CAS Number: 1141934-97-5
Molecular Formula: C₁₆H₂₆ClNO₂
Molecular Weight: 299.83600
Catalog: Research Areas Metabolic Disease
Create Date: 2016-04-22 17:51:03
Modify Date: 2024-01-11 22:42:20
Emixustat hydrochloride strongly inhibits 11-cis-retinol production with IC50 values of 232 ± 3 nM. IC50 value: 232 nM [1]Target: 11-cis-retinolEmixustat hydrochloride is a novel visual cycle modulator, in healthy volunteers. Oral Emixustat was safe and well tolerated when administered once daily for 14 days with minimal systemic adverse events reported. Evaluation of emixustat in subjects with geographic atrophy associated with dry age-related macular degeneration.[2]

Name	(1R)-3-amino-1-[3-(cyclohexylmethoxy)phenyl]propan-1-ol,hydrochloride
Synonyms	Emixustat HCl EMIXUSTAT HYDROCHLORIDE ACU-4429 HCl UNII-AP4OF2M98B Emixustat (hydrochloride)

Description	Emixustat hydrochloride strongly inhibits 11-cis-retinol production with IC50 values of 232 ± 3 nM. IC50 value: 232 nM [1]Target: 11-cis-retinolEmixustat hydrochloride is a novel visual cycle modulator, in healthy volunteers. Oral Emixustat was safe and well tolerated when administered once daily for 14 days with minimal systemic adverse events reported. Evaluation of emixustat in subjects with geographic atrophy associated with dry age-related macular degeneration.[2]
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
References	[1]. Kiser PD, et al. Catalytic mechanism of a retinoid isomerase essential for vertebrate vision. Nat Chem Biol. 2015 Jun;11(6):409-15. [2]. Kubota R, et al. Phase 1, dose-ranging study of emixustat hydrochloride (ACU-4429), a novel visual cycle modulator, in healthy volunteers. Retina. 2014 Mar;34(3):603-9.