1131981-29-7

1131981-29-7 structure
1131981-29-7 structure
  • Name: Glimepiride-d4-1
  • Chemical Name: Glimepiride-d4
  • CAS Number: 1131981-29-7
  • Molecular Formula: C24H30D4N4O5S
  • Molecular Weight: 494.64
  • Catalog: Research Areas Metabolic Disease
  • Create Date: 2018-06-07 18:59:29
  • Modify Date: 2024-01-20 13:22:26
  • Glimepiride-d4-1 is deuterium labeled Glimepiride. Glimepiride (Glimperide) is a medium-to-long acting sulfonylurea anti-diabetic compound with an ED50 of 182 μg/kg.

Name Glimepiride-d4
Synonyms Glimepiride D4
Description Glimepiride-d4-1 is deuterium labeled Glimepiride. Glimepiride (Glimperide) is a medium-to-long acting sulfonylurea anti-diabetic compound with an ED50 of 182 μg/kg.
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Geisen, K., Special pharmacology of the new sulfonylurea glimepiride. Arzneimittelforschung, 1988. 38(8): p. 1120-30.

[3]. Liu, F., et al., Glimepiride attenuates Abeta production via suppressing BACE1 activity in cortical neurons. Neurosci Lett, 2013. 557 Pt B: p. 90-4.

[4]. Basit, A., M. Riaz, and A. Fawwad, Glimepiride: evidence-based facts, trends, and observations (GIFTS). [corrected]. Vasc Health Risk Manag, 2012. 8: p. 463-72.

Molecular Formula C24H30D4N4O5S
Molecular Weight 494.64
Exact Mass 494.25000
PSA 133.06000
LogP 5.26540