117047-07-1

117047-07-1 structure

Name: 3'-Methoxypuerarin
Chemical Name: 3'-Methoxy Puerarin
CAS Number: 117047-07-1
Molecular Formula: C₂₂H₂₂O₁₀
Molecular Weight: 446.404
Catalog: Biochemical Plant extracts
Create Date: 2018-06-26 18:24:04
Modify Date: 2024-01-03 18:36:14
3'-Methoxypuerarin (3'-MOP) is an isoflavone extracted from radix puerariae that shows neuron protection activity.

Name	3'-Methoxy Puerarin
Synonyms	3'-MethoxyPuerarin 1,3-DICAFFEOYLQUINIC ACID (1S)-1,5-Anhydro-1-[7-hydroxy-3-(4-hydroxy-3-methoxyphenyl)-4-oxo-4H-chromen-8-yl]-D-glucitol 3-METHOXY PUERARIN D-Glucitol, 1,5-anhydro-1-C-[7-hydroxy-3-(4-hydroxy-3-methoxyphenyl)-4-oxo-4H-1-benzopyran-8-yl]-, (1S)- Methoxypuerarin, 3'- '-

Description	3'-Methoxypuerarin (3'-MOP) is an isoflavone extracted from radix puerariae that shows neuron protection activity.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease Natural Products >> Flavonoids
In Vivo	3'-Methoxypuerarin increases the number of surviving neurons in the hippocampal CA1 region and markedly reduces the number of apoptotic pyramidal neurons after ischemia/reperfusion injury. 3'-Methoxypuerarin can protect hippocampal neurons against I/R injury by inhibiting apoptosis[1].
Animal Admin	Rats[1] Male Wistar rats, weighing 260-320 g are randomly divided into three groups (n = 8 per group). [1] I/R+3'-MOP group: the rats undergo 8 minutes of ischemia and then 3 days of reperfusion. The 3'-Methoxypuerarin (60 mg/kg i.p.) is administrated at the moment of clamping of the carotid arteries. The rats receive daily i.p. injection of 3'-Methoxypuerarin for 3 days. [2] I/R group: the rats undergo 8 minutes of ischemia and 72 h of reperfusion. The same volume of solvent (35% polyethylene glycol solution) is administrated in the same way as 3'-Methoxypuerarin. [3] Control group: the rats undergo a sham operation. Vertebral and carotid arteries are exposed but not occluded. The rats receive a daily i.p. injection of 35% polyethylene glycol solution for 3 days[1].
References	[1]. Liu Y, et al. Protection by 3'-methoxypuerarin of rat hippocampal neurons against ischemia/reperfusion injury. Chin J Physiol. 2010 Apr 30;53(2):136-40.