3'-Methoxypuerarin structure
|
Common Name | 3'-Methoxypuerarin | ||
|---|---|---|---|---|
| CAS Number | 117047-07-1 | Molecular Weight | 446.404 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 706.0±60.0 °C at 760 mmHg | |
| Molecular Formula | C22H22O10 | Melting Point | 212-213℃ | |
| MSDS | N/A | Flash Point | 247.5±26.4 °C | |
Use of 3'-Methoxypuerarin3'-Methoxypuerarin (3'-MOP) is an isoflavone extracted from radix puerariae that shows neuron protection activity. |
| Name | 3'-Methoxy Puerarin |
|---|---|
| Synonym | More Synonyms |
| Description | 3'-Methoxypuerarin (3'-MOP) is an isoflavone extracted from radix puerariae that shows neuron protection activity. |
|---|---|
| Related Catalog | |
| In Vivo | 3'-Methoxypuerarin increases the number of surviving neurons in the hippocampal CA1 region and markedly reduces the number of apoptotic pyramidal neurons after ischemia/reperfusion injury. 3'-Methoxypuerarin can protect hippocampal neurons against I/R injury by inhibiting apoptosis[1]. |
| Animal Admin | Rats[1] Male Wistar rats, weighing 260-320 g are randomly divided into three groups (n = 8 per group). [1] I/R+3'-MOP group: the rats undergo 8 minutes of ischemia and then 3 days of reperfusion. The 3'-Methoxypuerarin (60 mg/kg i.p.) is administrated at the moment of clamping of the carotid arteries. The rats receive daily i.p. injection of 3'-Methoxypuerarin for 3 days. [2] I/R group: the rats undergo 8 minutes of ischemia and 72 h of reperfusion. The same volume of solvent (35% polyethylene glycol solution) is administrated in the same way as 3'-Methoxypuerarin. [3] Control group: the rats undergo a sham operation. Vertebral and carotid arteries are exposed but not occluded. The rats receive a daily i.p. injection of 35% polyethylene glycol solution for 3 days[1]. |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 706.0±60.0 °C at 760 mmHg |
| Melting Point | 212-213℃ |
| Molecular Formula | C22H22O10 |
| Molecular Weight | 446.404 |
| Flash Point | 247.5±26.4 °C |
| Exact Mass | 446.121307 |
| PSA | 170.05000 |
| LogP | 1.72 |
| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
| Index of Refraction | 1.696 |
| Storage condition | 2-8℃ |
| 3'-MethoxyPuerarin |
| 1,3-DICAFFEOYLQUINIC ACID |
| (1S)-1,5-Anhydro-1-[7-hydroxy-3-(4-hydroxy-3-methoxyphenyl)-4-oxo-4H-chromen-8-yl]-D-glucitol |
| 3-METHOXY PUERARIN |
| D-Glucitol, 1,5-anhydro-1-C-[7-hydroxy-3-(4-hydroxy-3-methoxyphenyl)-4-oxo-4H-1-benzopyran-8-yl]-, (1S)- |
| Methoxypuerarin, 3'- '- |