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125971-95-1

125971-95-1 structure
125971-95-1 structure
  • Name: Atorvastatin Acetonide tert-Butyl Ester
  • Chemical Name: tert-Butyl (4R,6R)-2-[[[6-(2-4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate
  • CAS Number: 125971-95-1
  • Molecular Formula: C40H47FN2O5
  • Molecular Weight: 654.810
  • Catalog: Research Areas Others
  • Create Date: 2018-05-25 08:00:00
  • Modify Date: 2024-01-05 17:29:15
  • Atorvastatin acetonide tert-butyl ester is a useful pharmaceutical intermediate in the preparation of Atorvastatin salts. Atorvastatin is an orally active HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids[1].

Name tert-Butyl (4R,6R)-2-[[[6-(2-4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate
Synonyms tert-butyl [(4R,6R)-6-{2-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxan-4-yl]acetate
Atorvastatin Acetonide tert-Butyl Ester
MFCD08458280
T6O COTJ B1 B1 D1VOX1&1&1 F2- AT5NJ BY1&1 CVMR& DR ER DF &&(4R,6R)- Form
Atorvastatin intermediate L1
tert-Butyl [(4R,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxan-4-yl]acetate
1,3-Dioxane-4-acetic acid, 6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R,6R)-
2-Methyl-2-propanyl [(4R,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxan-4-yl]acetate
Atorvastatin calciuM interMediate
(4R-CIS)-[1,1-DIMETHYLETHYL-6-[(2-FLUOROPHENYL)-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO) CARBONYL]-1H-PYRROL-1-YL]ETHYL]-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE
Atorvastatin Impurity 30
Description Atorvastatin acetonide tert-butyl ester is a useful pharmaceutical intermediate in the preparation of Atorvastatin salts. Atorvastatin is an orally active HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids[1].
Related Catalog
References

[1]. Process for preparing amorphous (4r-cis)-6-[2-[3-phenyl-4-(phenylcarbamoyl)-2-(4-fluorophenyl)-5-(1-methylethyl)-pyrrol-1-yl]-ethyl]-2,2-dimethyl-[1,3]-dioxane-4-yl-acetic acid. WO2005063741A1.

Density 1.1±0.1 g/cm3
Boiling Point 678.0±55.0 °C at 760 mmHg
Melting Point 144-148ºC
Molecular Formula C40H47FN2O5
Molecular Weight 654.810
Flash Point 363.9±31.5 °C
Exact Mass 654.346924
PSA 78.79000
LogP 7.78
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.569
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 3