Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Atorvastatin lactone
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Purity: 98.0%
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125995-03-1

125995-03-1 structure

Name: Atorvastatin lactone
Chemical Name: 5-(4-fluorophenyl)-1-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-N,4-diphenyl-2-propan-2-ylpyrrole-3-carboxamide
CAS Number: 125995-03-1
Molecular Formula: C₃₃H₃₃FN₂O₄
Molecular Weight: 540.625
Catalog: Signaling Pathways Metabolic Enzyme/Protease HMG-CoA Reductase (HMGCR)
Create Date: 2018-03-23 08:00:00
Modify Date: 2026-06-30 16:28:38
Atorvastatin lactone is a prodrug form of atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor[1].

Name	5-(4-fluorophenyl)-1-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-N,4-diphenyl-2-propan-2-ylpyrrole-3-carboxamide
Synonyms	Atorvastatin calcium-6 1H-Pyrrole-3-cboxamide, 5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl] (4R,6R)-6-[2-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-(phenylcbamoyl)-1H-pyrrol-1-yl]ethyl]-4-hydroxytetrahydro-2H-pyran-2-one (Atorvastatin Lactone) Atorvastatin RC H ATORVASTATIN LACTONE Atorvastatin Calcium Hydrate impurity H Atorvastatin Calcium Trihydrate Impurity H Dioxide Atorvastatin Lactone Dioxide Atorvastatin calcium impurity H Atorvastatin Impurity H RC H)Ator. Lacton PD-130694 5-(4-Fluorophenyl)-1-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-N,4-di(phenyl)-2-propan-2-ylpyrrole-3-carboxamide (3R,5R)-7-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-yl]-3,5-dihydroxyhtanoic acid 1,5-lactone Atorvastatin Impurity H (Atorvastatin Related Compound H, Atorvastatin Lactone) 5-(4-fluorophenyl)-1-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-N,4-diphenyl-2-(propan-2-yl)-1H-pyrrole-3-cboxamide Atorvastatin Impurity 23 Atorvastatin Lactone (Atorvastatin Impurity H) 1-[2-[[(2R)-Tetrahydro-4β-hydroxy-6-oxo-2H-pyran]-2α-yl]ethyl]-5-(4-fluorophenyl)-2-isopropyl-4,N-diphenyl-1H-pyrrole-3-cboxamide Atorvastatin impurity 9/Atorvastatin Impurity H/Atorvastatin Lactone/5-(4-fluorophenyl)-2-(1-methyl-ethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro- hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-cboxamide Atorvastatin Impurity H Atorvastatin Impurity H (Atorvastatin Lactone) Atorvastatin d-Lactone Atorvastatin lactone, 10 mM in DMSO 5-(4-Fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-cboxamide Atorvastatin Calcium Impurity D Benzeneacetamide,a-cyano-4-methoxy Atorvastatin Related Compound H 5-(4-fluorophenyl)-1-(2-((2R,4R) 5-(4-Fluorophenyl)-1-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide 5-(4-Fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide (4R,6R)-6-{2-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcbamoyl)pyrrol-1-yl]ethyl}-4-hydroxytetrahydro-2H-pyran-2-one (4R,6R)-6-[2-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-(phenylcbamoyl)-1H-pyrrol-1-yl]ethyl Atorvastatin D5 LactoneQ: What is Atorvastatin D5 Lactone Q: What is the CAS Number of Atorvastatin D5 Lactone Q: What is the storage condition of Atorvastatin D5 Lactone Q: What e the applications of Atorvastatin D5 Lactone LACTONE IMPURITY(IMP-H) Atorvastatin lactone ( imp H) Atorvastatin IMp H RCH) AtorvastatinImpurityH-d5 Atorvastatin Related Compound H (20 mg) (5-(4-Fluorophenyl)-1-{2-[(2R, 4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-cboxamide) (4R,6R)-6-[2-[2-(4-Fluorophenyl)-5 Atorvastatin lactone impurity H) 5-(4-fluorophenyl)-1-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-N,4-diphenyl-2-propan-2-ylpyrrole-3-cboxamide (RS) Atorvastatin Lactone Atorvastatin Related Compound H (1044582)Q: What is Atorvastatin Related Compound H Q: What is the CAS Number of Atorvastatin Related Compound H Atorvastatin Impurity H/ Atorvastatin Related Compound H (Atorvastatin Lactone) Atorvastatin LactoneQ: What is Atorvastatin Lactone Q: What is the CAS Number of Atorvastatin Lactone Q: What is the storage condition of Atorvastatin Lactone Q: What e the applications of Atorvastatin Lactone (4R,6R)-6-[2-[2-(4-flfluorophenyl)-5-(1-methylethyl)-3- phenyl-4-(phenylcbamoyl)-1H-pyrrol-1-yl]ethyl]-4- hydroxytetrahydro-2H-pyran-2-one 4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide

Description	Atorvastatin lactone is a prodrug form of atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR) Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
References	[1]. Valesky RJ, et al. Automated enzyme inhibition assay method for the determination of atorvastatin-derived HMG-CoA reductase inhibitors in human plasma using radioactivity detection. J Pharmacol Toxicol Methods. 2008 Jan-Feb;57(1):61-9.

Density	1.2±0.1 g/cm3
Boiling Point	674.8±55.0 °C at 760 mmHg
Melting Point	103-106ºC
Molecular Formula	C₃₃H₃₃FN₂O₄
Molecular Weight	540.625
Flash Point	361.9±31.5 °C
Exact Mass	540.242432
PSA	80.56000
LogP	4.30
Vapour Pressure	0.0±2.2 mmHg at 25°C
Index of Refraction	1.617

RIDADR	UN 2811 6.1 / PGII
HS Code	2934999090

Precursor 9
842163-03-5 134523-00-5 581772-29-4 125971-86-0
125971-96-2 340266-37-7 125971-95-1 67-56-1
110862-44-7
DownStream 1
134523-01-6

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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