820-11-1

820-11-1 structure

Name: 3-phosphoglyceric acid
Chemical Name: 3-phosphoglyceric acid
CAS Number: 820-11-1
Molecular Formula: C₃H₇O₇P
Molecular Weight: 183.03300
Create Date: 2017-05-25 15:32:50
Modify Date: 2025-08-25 15:15:23
3-Phosphoglyceric acid is a metabolic intermediate in both glycolysis and the Calvin cycle. 3-Phosphoglyceric acid is involved in alveolar macrophage epigenetic regulation.

Name	3-phosphoglyceric acid
Synonyms	D-3-phosphoglycerate 4gwk 3-phospho-D-glyceric acid (2R)-2-hydroxy-3-phosphonatooxypropanoate 3-phospho-D-glycerate D-glycerate-3-P D-Glycerate 3-phosphate 3fjg 3-P-D-glycerate 3-phosphonato-D-glycerate

Description	3-Phosphoglyceric acid is a metabolic intermediate in both glycolysis and the Calvin cycle. 3-Phosphoglyceric acid is involved in alveolar macrophage epigenetic regulation.
In Vitro	3-Phosphoglyceric acid (400 µM; 24 hours; BMDMs) treatment enhances Spp1 transcription in VHL-deficient macrophages, and the reduced H3K4me3 modification is also reversed[1]. 3-Phosphoglyceric treatment significantly augmentes gene expression as well as H3K4me3 deposition of Spp1 in IL-4-stimulated macrophages[1]. In yeast, 3-Phosphoglyceric acid acts as a metabolic checkpoint for the formation of a multicomponent enzyme complex including serine metabolic enzymes and pyruvate kinase isoform 2 (PKM2) homologue, which senses both serine metabolism and glycolysis and regulates H3K4 methylation and histone phosphorylation[1]. RT-PCR[1] Cell Line: Bone marrow-derived macrophages (BMDMs) Concentration: 400 µM Incubation Time: 24 hours Result: Enhanced Spp1 transcription in VHL-deficient macrophages, and the reduced H3K4me3 modification was also reversed.
References	[1]. Zhang W, et al. The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation. J Exp Med. 2018 Dec 3;215(12):3180-3193.