Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Docusate sodium
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Docusate sodium
Price: ￥348.0/500g ￥118.0/100g
Purity: 96.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Docusate Sodium
Price: $100.0/100mg $200.0/250mg $400.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Docusate Sodium
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Docusate sodium
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

577-11-7

577-11-7 structure

Name: Docusate sodium
Chemical Name: Docusate sodium
CAS Number: 577-11-7
Molecular Formula: C₂₀H₃₇NaO₇S
Molecular Weight: 444.558
Catalog: API Digestive system medication Laxative antidiarrheal
Create Date: 2018-08-05 20:10:24
Modify Date: 2024-01-01 22:12:52
Docusate Sodium is a laxative used to treat constipation, for constipation due to the use of opiates it maybe used with a stimulant laxative, can be taken by mouth or rectally.

Name	Docusate sodium
Synonyms	sbo Octowet Nikkol OTP 100 DOSS Astrowet 608 DIOX Dioctyl sodium sulfosuccinate Docusate sodium salt Gemtex SC 40 Nikkol OTP 100S Sanseparer 100 Geropon SS-O 75 Rapisol B 90 nevax Bis(ethylhexyl) ester of sodium sulfosuccinic acid Pentex 99 Dioctyl ester of sodium sulfosuccinate Empimin OP 70 Neocol YSK Sunnol LDF 110 Aerosol OT 100 Di-(2-ethylhexyl) sodium sulfosuccinate sv102 colace Triton GR 5 Sodium 1,4-bis[(2-ethylhexyl)oxy]-1,4-dioxo-2-butanesulfonate Newcol 290M Rapisol B 80 Rewopol SBDO 70 sodium bis(2-ethylhexyl) sulfosuccinate Sulfobutanedioic acid 1,4-bis(2-ethylhexyl) ester sodium salt Gemtex SC Lumiten I-RA Valsol OT Bis(2-ethylhexyl)sodium sulfosuccinate Rapisol A 30 Solusol doxol Neopelex OTP Airrol OP Newcol 291M Lankropol KO 2 Triton GR 7M Newkalgen EP 60P Solovet revac Geropon DOS Astrowet O 70PG Dioctyl sulfosuccinate sodium salt Marlinat DF 8 Astrowet O 75 Persol KMN 3 Monawet MO 70R coprol Nikkol OTP 75 Triton GR 7ME Aerosol OT 75PG Sodium 1,4-bis[(2-ethylhexyl)oxy]-1,4-dioxobutane-2-sulfonate Aerosol OT-S Spilon 8 Jamylene Sodium Di(2-ethylhexyl) Sulfosuccinate Pelex OT Empimin OT 75 Butanedioic acid, 2-sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt (1:1) DSS Rapisol A 80 Triton GR 5M Succinate STD Pelex OT-P Sulfosuccinic Acid 1,4-Bis(2-ethylhexyl) Ester S-Sodium Salt Genopur SB 1970J Lutensit A-BO Bis(2-ethylhexyl) Sulfosuccinate Sodium Salt Lutensit A-BOS Docusate sodium Neocol P Di(2-ethylhexyl)sulfosuccinic acid, sodium salt sodium dioctyl sulfosuccinate Manoxol Newkalgen EP 70G Surfonic DOS 75PG BIS(2-ETHYLHEXYL) SULFOSUCCINATE, SODIUM SALT Monawet M 085P Pionin A 51B Geropon WT 27 EINECS 209-406-4 NK-EP 70G Warcowet 060 Drewfax 007 Aerosol OT 94 Newcol 291EG AOT Nonit Sodium Docusate Airrol CT 1 Isoprotanc Manoxol OP MFCD00012455 Monawet MO 70 Sanmorin OT 70N Freetex OT Rapisol B 30 KM 10-1610 Monawet MO 70E Docusate (Sodium)

Description	Docusate Sodium is a laxative used to treat constipation, for constipation due to the use of opiates it maybe used with a stimulant laxative, can be taken by mouth or rectally.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others

Density	1.1
Melting Point	173-179 °C(lit.)
Molecular Formula	C₂₀H₃₇NaO₇S
Molecular Weight	444.558
Flash Point	199ºC
Exact Mass	444.215759
PSA	118.18000
LogP	4.89030
Storage condition	2-8°C
Stability	Stable. Combustible. Incompatible with strong oxidizing agents.
Water Solubility	1.5 g/100 mL (25 ºC)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WN0525000

CHEMICAL NAME :: Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt

CAS REGISTRY NUMBER :: 577-11-7

LAST UPDATED :: 199710

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C20-H38-O7-S.Na

MOLECULAR WEIGHT :: 445.63

WISWESSER LINE NOTATION :: 2Y2&3OVYSWQ1VO3Y2&2 &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 82,377,1944

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AROPAW Archives of Ophthalmology (Chicago). (AMA, 535 N. Dearborn St., Chicago, IL 60610) New series: V.1-44(3), 1929-50; V.64- 1960- Volume(issue)/page/year: 34,99,1945

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 38,428,1949 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947- Volume(issue)/page/year: 13,469,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 590 mg/kg

TOXIC EFFECTS :: Vascular - structural changes in vessels

REFERENCE :: BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971- Volume(issue)/page/year: 7,161,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2643 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 1,89,1977/1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 38,428,1949 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 42 gm/kg/12W-C

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Metabolism (Intermediary) - lipids including transport

REFERENCE :: BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971- Volume(issue)/page/year: 9,159,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 12 gm/kg/30D-I

TOXIC EFFECTS :: Related to Chronic Data - death

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 38,428,1949

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 84 mg/kg/24W-I

TOXIC EFFECTS :: Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea Related to Chronic Data - death

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 25,175,1943 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 8820 mg/kg

SEX/DURATION :: multigeneration

TOXIC EFFECTS :: Reproductive - Effects on Newborn - other postnatal measures or effects

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 15,53,1990 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83280 No. of Facilities: 3817 (estimated) No. of Industries: 53 No. of Occupations: 74 No. of Employees: 45527 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83280 No. of Facilities: 11668 (estimated) No. of Industries: 95 No. of Occupations: 100 No. of Employees: 180694 (estimated) No. of Female Employees: 49329 (estimated)

Symbol	GHS05
Signal Word	Danger
Hazard Statements	H315-H318
Precautionary Statements	P280-P305 + P351 + P338 + P310
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R22;R36/37/38
Safety Phrases	S26-S39-S37/39-S36
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	WN0525000
HS Code	2914509090

142-16-5

577-11-7

Literature: US7981932 B2, ; Page/Page column 4 ;

Precursor 1
142-16-5
DownStream 0

HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

577-11-7	106819-58-3
121183-10-6	86878-53-7
175736-89-7	1144097-30-2
6100-16-9	68057-99-8
79060-88-1	30605-57-3
1158522-08-7	1416230-43-7
940364-43-2	134104-43-1
131615-57-1	6906-52-1
930439-75-1	2305297-60-1
1018584-77-4	1375289-11-4