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577-11-7

577-11-7 structure
577-11-7 structure
  • Name: Docusate sodium
  • Chemical Name: Docusate sodium
  • CAS Number: 577-11-7
  • Molecular Formula: C20H37NaO7S
  • Molecular Weight: 444.558
  • Catalog: API Digestive system medication Laxative antidiarrheal
  • Create Date: 2018-08-05 20:10:24
  • Modify Date: 2025-08-20 01:18:33
  • Docusate Sodium is a laxative used to treat constipation, for constipation due to the use of opiates it maybe used with a stimulant laxative, can be taken by mouth or rectally.
Name Docusate sodium
Synonyms sbo
Octowet
Nikkol OTP 100
DOSS
Astrowet 608
DIOX
Dioctyl sodium sulfosuccinate
Docusate sodium salt
Gemtex SC 40
Nikkol OTP 100S
Sanseparer 100
Geropon SS-O 75
Rapisol B 90
nevax
Bis(ethylhexyl) ester of sodium sulfosuccinic acid
Pentex 99
Dioctyl ester of sodium sulfosuccinate
Empimin OP 70
Neocol YSK
Sunnol LDF 110
Aerosol OT 100
Di-(2-ethylhexyl) sodium sulfosuccinate
sv102
colace
Triton GR 5
Sodium 1,4-bis[(2-ethylhexyl)oxy]-1,4-dioxo-2-butanesulfonate
Newcol 290M
Rapisol B 80
Rewopol SBDO 70
sodium bis(2-ethylhexyl) sulfosuccinate
Sulfobutanedioic acid 1,4-bis(2-ethylhexyl) ester sodium salt
Gemtex SC
Lumiten I-RA
Valsol OT
Bis(2-ethylhexyl)sodium sulfosuccinate
Rapisol A 30
Solusol
doxol
Neopelex OTP
Airrol OP
Newcol 291M
Lankropol KO 2
Triton GR 7M
Newkalgen EP 60P
Solovet
revac
Geropon DOS
Astrowet O 70PG
Dioctyl sulfosuccinate sodium salt
Marlinat DF 8
Astrowet O 75
Persol KMN 3
Monawet MO 70R
coprol
Nikkol OTP 75
Triton GR 7ME
Aerosol OT 75PG
Sodium 1,4-bis[(2-ethylhexyl)oxy]-1,4-dioxobutane-2-sulfonate
Aerosol OT-S
Spilon 8
Jamylene
Sodium Di(2-ethylhexyl) Sulfosuccinate
Pelex OT
Empimin OT 75
Butanedioic acid, 2-sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt (1:1)
DSS
Rapisol A 80
Triton GR 5M
Succinate STD
Pelex OT-P
Sulfosuccinic Acid 1,4-Bis(2-ethylhexyl) Ester S-Sodium Salt
Genopur SB 1970J
Lutensit A-BO
Bis(2-ethylhexyl) Sulfosuccinate Sodium Salt
Lutensit A-BOS
Docusate sodium
Neocol P
Di(2-ethylhexyl)sulfosuccinic acid, sodium salt
sodium dioctyl sulfosuccinate
Manoxol
Newkalgen EP 70G
Surfonic DOS 75PG
BIS(2-ETHYLHEXYL) SULFOSUCCINATE, SODIUM SALT
Monawet M 085P
Pionin A 51B
Geropon WT 27
EINECS 209-406-4
NK-EP 70G
Warcowet 060
Drewfax 007
Aerosol OT 94
Newcol 291EG
AOT
Nonit
Sodium Docusate
Airrol CT 1
Isoprotanc
Manoxol OP
MFCD00012455
Monawet MO 70
Sanmorin OT 70N
Freetex OT
Rapisol B 30
KM 10-1610
Monawet MO 70E
Docusate (Sodium)
Description Docusate Sodium is a laxative used to treat constipation, for constipation due to the use of opiates it maybe used with a stimulant laxative, can be taken by mouth or rectally.
Related Catalog
Density 1.1
Melting Point 173-179 °C(lit.)
Molecular Formula C20H37NaO7S
Molecular Weight 444.558
Flash Point 199ºC
Exact Mass 444.215759
PSA 118.18000
LogP 4.89030
Storage condition 2-8°C
Stability Stable. Combustible. Incompatible with strong oxidizing agents.
Water Solubility 1.5 g/100 mL (25 ºC)

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WN0525000
CHEMICAL NAME :
Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt
CAS REGISTRY NUMBER :
577-11-7
LAST UPDATED :
199710
DATA ITEMS CITED :
17
MOLECULAR FORMULA :
C20-H38-O7-S.Na
MOLECULAR WEIGHT :
445.63
WISWESSER LINE NOTATION :
2Y2&3OVYSWQ1VO3Y2&2 &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 82,377,1944
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
AROPAW Archives of Ophthalmology (Chicago). (AMA, 535 N. Dearborn St., Chicago, IL 60610) New series: V.1-44(3), 1929-50; V.64- 1960- Volume(issue)/page/year: 34,99,1945
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 38,428,1949 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947- Volume(issue)/page/year: 13,469,1962
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
590 mg/kg
TOXIC EFFECTS :
Vascular - structural changes in vessels
REFERENCE :
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971- Volume(issue)/page/year: 7,161,1974
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2643 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 1,89,1977/1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 38,428,1949 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
42 gm/kg/12W-C
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971- Volume(issue)/page/year: 9,159,1976
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
12 gm/kg/30D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 38,428,1949
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
84 mg/kg/24W-I
TOXIC EFFECTS :
Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea Related to Chronic Data - death
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 25,175,1943 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
8820 mg/kg
SEX/DURATION :
multigeneration
TOXIC EFFECTS :
Reproductive - Effects on Newborn - other postnatal measures or effects
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 15,53,1990 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83280 No. of Facilities: 3817 (estimated) No. of Industries: 53 No. of Occupations: 74 No. of Employees: 45527 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83280 No. of Facilities: 11668 (estimated) No. of Industries: 95 No. of Occupations: 100 No. of Employees: 180694 (estimated) No. of Female Employees: 49329 (estimated)
Symbol GHS05
GHS05
Signal Word Danger
Hazard Statements H315-H318
Precautionary Statements P280-P305 + P351 + P338 + P310
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful
Risk Phrases R22;R36/37/38
Safety Phrases S26-S39-S37/39-S36
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS WN0525000
HS Code 2914509090
142-16-5 structure

142-16-5

~%

577-11-7 structure

577-11-7

Literature: US7981932 B2, ; Page/Page column 4 ;
Precursor  1

DownStream  0

HS Code 2914509090
Summary HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%
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