4442-53-9
4442-53-9 structure
- Name: 1,4-BENZODIOXAN-5-CARBOXYLIC ACID
- Chemical Name: 2,3-Dihydro-1,4-benzodioxine-5-carboxylic acid
- CAS Number: 4442-53-9
- Molecular Formula: C9H8O4
- Molecular Weight: 180.157
- Create Date: 2018-10-04 11:33:07
- Modify Date: 2026-07-29 10:21:19
| Name | 2,3-Dihydro-1,4-benzodioxine-5-carboxylic acid |
|---|---|
| Synonyms |
1,4-Benzodioxan-5-carboxylic acid
1,4-BENZODIOXANE-5-CBOXYLIC ACID 2,3-dihydro-1,4-benzodioxin-5-cboxylic acid 2,3-dihydro-1,4-benzodioxane-5-cboxylic acid 2,3,4a,8a-tetrahydro-1,4-benzodioxin-5-cboxylic acid Compound 3344 hydrochloride MFCD00239415 5-Cboxy-2,3-dihydro-1,4-benzodioxine, 1,4-Benzodioxane-5-cboxylic acid 1,4-Benzodioxan-5-cboxylic acid/2,3-Dihydro-1,4-Benzodioxine-5-Cboxylic Acid 2,3-dihydrobenzo[b][1,4]dioxine-5-cboxylic acid 5-CBOXY-1,4-BENZODIOXANE 3-Dihydro-1 2,3-dihydro-1,4-benzodioxane-5-carboxylic acid EINECS 224-670-0 2,3-Ethylenedioxybenzoic Acid Compound 3344 hydrochloride (2368-8 free base) 2,3-Dihydrobenzo[b][1,4]dioxine-5-carboxylic acid 2,3-Dihydro-1,4-benz 1,4-Benzodioxine-5-cboxylicacid 2,3-DIHYDRO-1,4-BENZODIOXAN-5-CBOXYLIC ACID 4-(2 7,10-dioxabicyclo[4.4.0]deca-1,3,5-triene-2-cboxylic acid 1,4-Benzodioxan-5-cboxylic acid 2,3-DIAMINO-4-BROMOPYRIDINE 1,4-Benzodioxane-5-cboxylicAcid> 4-benzodioxine-5-cboxylic acid 2,3-Dihydro-1,4-benzodioxane-5-hydroxyacid 2,3-DIHYDRO-1,4-BENZODIOXINE-5-CBOXYLIC ACID 1,4-Benzodioxin-5-cboxylic acid, 2,3-dihydro 1,4-Benzodioxane-5-carboxylic Acid 2,3-Dihydro-1,4-benzodioxin-5-carboxylic acid 5-Carboxy-2,3-dihydro-1,4-benzodioxin 2,3-DIHYDRO-BENZO[1,4]DIOXINE-5-CBOXYLIC ACID 4-benzodioxin-5-yl)-~{N}-[3-[(dimethylamino)methyl]phenyl]-2-methoxy-aniline hydrochloride(2368-8 free base) |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 334.1±41.0 °C at 760 mmHg |
| Melting Point | 90-94 °C(lit.) |
| Molecular Formula | C9H8O4 |
| Molecular Weight | 180.157 |
| Flash Point | 139.3±21.1 °C |
| Exact Mass | 180.042252 |
| PSA | 55.76000 |
| LogP | 1.46 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.587 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36-S37/39-S36/37/38 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2932999099 |
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4442-53-9 |
| Literature: GLENMARK PHARMACEUTICALS S.A.; GHARAT, Laxmikant Atmaram; MUTHUKAMAN, Nagarajan; DESHMUKH, Sanjay; KHAIRATKAR-JOSHI, Neelima; KATTIGE, Vidya Ganapati Patent: WO2013/153535 A1, 2013 ; Location in patent: Page/Page column 63 ; |
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4442-53-9 |
| Literature: Adir et Compagnie Patent: US5919814 A1, 1999 ; |
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4442-53-9 |
| Literature: Duan, Yong-Tao; Yao, Yong-Fang; Huang, Wei; Makawana, Jigar A.; Teraiya, Shashikant B.; Thumar, Nilesh J.; Tang, Dan-Jie; Tao, Xiang-Xiang; Wang, Zhong-Chang; Jiang, Ai-Qin; Zhu, Hai-Liang Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 11 p. 2947 - 2954 |
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4442-53-9 |
| Literature: GLENMARK PHARMACEUTICALS S.A.; GHARAT, Laxmikant Atmaram; MUTHUKAMAN, Nagarajan; DESHMUKH, Sanjay; KHAIRATKAR-JOSHI, Neelima; KATTIGE, Vidya Ganapati Patent: WO2013/153535 A1, 2013 ; |
| Precursor 4 | |
|---|---|
| DownStream 10 | |
![2,3-Dihydrobenzo[b][1,4]dioxine-5-carboxamide structure](https://image.chemsrc.com/caspic/357/349550-81-8.png)
![8-AMINO-2,3-DIHYDROBENZO[B][1,4]DIOXINE-5-CARBOXYLIC ACID structure](https://image.chemsrc.com/caspic/129/66411-22-1.png)
![2, 3-Dihydrobenzo[b][1, 4]dioXnne-5-carbonitrile structure](https://image.chemsrc.com/caspic/302/148703-14-4.png)
![6,7-DIBROMO-2,3-DIHYDROBENZO[B][1,4]DIOXINE-5-CARBOXYLIC ACID structure](https://image.chemsrc.com/caspic/146/66411-17-4.png)
![6,7-DIBROMO-8-NITRO-2,3-DIHYDROBENZO[B][1,4]DIOXINE-5-CARBOXYLIC ACID structure](https://image.chemsrc.com/caspic/108/66411-18-5.png)
| HS Code | 2932999099 |
|---|---|
| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |