3475-39-6

3475-39-6 structure

Name: 1,1,3-Tribromoacetone
Chemical Name: 1,1,3-tribromopropan-2-one
CAS Number: 3475-39-6
Molecular Formula: C₃H₃Br₃O
Molecular Weight: 294.767
Catalog: Signaling Pathways Others Others
Create Date: 2018-07-14 19:44:28
Modify Date: 2024-01-02 17:13:52
1,1,3-Tribromoacetone is an impurity of methotrexate[1]. Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis[1].

Name	1,1,3-tribromopropan-2-one
Synonyms	1,1,3-Tribromoacetone 1,1,3-tribromopropanone 1,1,3-Tribrom-aceton 1,1,3-tribromo-propan-2-one 1,3-Tribromoacetone 2-Propanone, 1,1,3-tribromo- 1,1,3-tribromo-2-propanone 2-Propanone,1,3-tribromo

Description	1,1,3-Tribromoacetone is an impurity of methotrexate[1]. Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vivo	Methotrexate (Amethopterin) reduces thymus and spleen indices of mice. Methotrexate markedly decreases white blood cells, thymic and splenic lymphocytes at dose ≥5 mg/kg. However, there is a significant difference between the treatment plus control group and the model group (p<0.01). The combination of grape seed proanthocyanidins and Siberian ginseng eleutherosides obviously diminishes the effects of Methotrexate exposure on indices of thymus and spleens in mice[2]. Methotrexate (MTX) (2 mg/kg; i.p.; once in a week for 5 weeks) is effective in Freund's complete adjuvant-induced arthritis. The combination of Methotrexate (1 mg/kg; i.p.; once in a week for 5 weeks) and Curcumin (30 mg/kg and 100 mg/kg, thrice a week for 5 weeks; i.p.) shows a significant anti-arthritic action and protection from hematological toxicity[3].
References	[1]. Balwant Singh, et al. Process for the preparation of high purity methotrexate and derivatives thereof. Patent US4374987A 87A [2]. [2].Swierkot J, et al. Methotrexate in rheumatoid arthritis. Pharmacol Rep. 2006 Jul-Aug;58(4):473-92 [3]. Banji D, et al. Evaluation of the concomitant use of methotrexate and curcumin on Freund's complete adjuvant-induced arthritis and hematological indices in rats. Indian J Pharmacol. 2011;43(5):546-550.

Density	2.6±0.1 g/cm3
Boiling Point	266.2±25.0 °C at 760 mmHg
Molecular Formula	C₃H₃Br₃O
Molecular Weight	294.767
Flash Point	115.1±9.7 °C
Exact Mass	291.773376
PSA	17.07000
LogP	3.25
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.595

HS Code	2914700090

Precursor 10
106-96-7 26307-21-1 62012-16-2 67-64-1
816-39-7 867-54-9 64-19-7 7732-18-5
7726-95-6 10035-10-6
DownStream 5
119-24-4 1609-92-3 19741-14-1 6214-22-8
636-38-4

HS Code	2914700090
Summary	HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

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