124858-35-1

124858-35-1 structure

Name: Nadifloxacin
Chemical Name: nadifloxacin
CAS Number: 124858-35-1
Molecular Formula: C₁₉H₂₁FN₂O₄
Molecular Weight: 360.379
Catalog: API Synthetic anti-infective drugs Quinolone
Create Date: 2018-03-16 08:00:00
Modify Date: 2024-01-02 11:53:20
Nadifloxacin(OPC7251) is a topical fluoroquinolone antibiotic for the treatment of acne vulgaris. Target: AntibacterialNadifloxacin is a potent, broad-spectrum, quinolone agent approved for topical use in acne vulgaris and skin infections. Nadifloxacin inhibits the enzyme DNA gyrase that is involved in bacterial DNA synthesis and replication, thus inhibiting the bacterial multiplication. In vitro studies of nadifloxacin show potent and broad-spectrum antibacterial activity against aerobic Gram-positive, Gram-negative and anaerobic bacteria. Additionally, studies also suggest that the effectiveness of nadifloxacin in inflammatory acne lesions may be attributed to its inhibitory effect on pro-inflammatory cytokines like interleukin (IL)-1α, IL-6, and IL-8 which also play an important role in acne pathogenesis [1, 2].

Name	nadifloxacin
Synonyms	9-Fluoro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid (±)-9-Fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic Acid Nadiflox Activon 1H,5H-Benzo[ij]quinolizine-2-carboxylic acid, 9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo- Acuatim Jinofloxacin Nadifloxacin 9-Fluoro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid Nadixa Nadoxin MFCD00865081

Description	Nadifloxacin(OPC7251) is a topical fluoroquinolone antibiotic for the treatment of acne vulgaris. Target: AntibacterialNadifloxacin is a potent, broad-spectrum, quinolone agent approved for topical use in acne vulgaris and skin infections. Nadifloxacin inhibits the enzyme DNA gyrase that is involved in bacterial DNA synthesis and replication, thus inhibiting the bacterial multiplication. In vitro studies of nadifloxacin show potent and broad-spectrum antibacterial activity against aerobic Gram-positive, Gram-negative and anaerobic bacteria. Additionally, studies also suggest that the effectiveness of nadifloxacin in inflammatory acne lesions may be attributed to its inhibitory effect on pro-inflammatory cytokines like interleukin (IL)-1α, IL-6, and IL-8 which also play an important role in acne pathogenesis [1, 2].
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Inflammation/Immunology
References	[1]. Jacobs, M.R. and P.C. Appelbaum, Nadifloxacin: a quinolone for topical treatment of skin infections and potential for systemic use of its active isomer, WCK 771. Expert Opin Pharmacother, 2006. 7(14): p. 1957-66. [2]. Choudhury, S., et al., Efficacy and safety of topical nadifloxacin and benzoyl peroxide versus clindamycin and benzoyl peroxide in acne vulgaris: A randomized controlled trial. Indian J Pharmacol, 2011. 43(6): p. 628-31.

RIDADR	NONH for all modes of transport

1128-61-6

124858-35-1

Literature: Chemical and Pharmaceutical Bulletin, , vol. 37, # 8 p. 2103 - 2108

80290-18-2

124858-35-1

Literature: Chemical and Pharmaceutical Bulletin, , vol. 37, # 8 p. 2103 - 2108

5382-16-1

77483-92-2

~24%

124858-35-1

Literature: Chemical and Pharmaceutical Bulletin, , vol. 37, # 8 p. 2103 - 2108

79085-71-5

124858-35-1

Literature: Chemical and Pharmaceutical Bulletin, , vol. 37, # 8 p. 2103 - 2108