100427-26-7

100427-26-7 structure

Name: Lercanidipine
Chemical Name: 5-O-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS Number: 100427-26-7
Molecular Formula: C₃₆H₄₁N₃O₆
Molecular Weight: 611.727
Catalog: API Circulatory system medication Calcium channel blocker
Create Date: 2018-08-31 09:57:29
Modify Date: 2024-01-03 12:06:17
Lercanidipine is a calcium channel blocker of the dihydropyridine class.Target: Calcium ChannelLercanidipine is a calcium channel blocker of the dihydropyridine class, which works by relaxing and opening the blood vessels allowing the blood to circulate more freely around the body. Lercanidipine was effective and well-tolerated in patients with mild-to-moderate hypertension in the daily practice. The effectiveness and safety of the drug were independent of the degree of cardiovascular risk [1, 2].

Name	5-O-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Synonyms	1-[(3,3-diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 3-O-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 5-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-[(3,3-Diphenylpropyl)methylamino]-1,1-dimethylethyl Methyl Ester lercarnidipine 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester methyl 1,1,N-trimethyl-N-(3,3-diphenylpropyl)-2-aminoethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-pyridine-3,5-dicarboxylate masnidipine Methyl 1,1-Dimethyl-2-[N-(3,3-diphenylpropyl)-N-methylamino]ethyl 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methyl-2-propanyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate Lercanidipine [INN] UNII:V7XTJ4R0BH Lercanil (TN) (±)-2-((3,3-diphenylpropyl)(methyl)amino)-1,1-dimethylethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate REC 15-2375 MFCD00867978 UNII-V7XTJ4R0BH 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester Lercanidipine

Description	Lercanidipine is a calcium channel blocker of the dihydropyridine class.Target: Calcium ChannelLercanidipine is a calcium channel blocker of the dihydropyridine class, which works by relaxing and opening the blood vessels allowing the blood to circulate more freely around the body. Lercanidipine was effective and well-tolerated in patients with mild-to-moderate hypertension in the daily practice. The effectiveness and safety of the drug were independent of the degree of cardiovascular risk [1, 2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cardiovascular Disease
References	[1]. Barrios, V., et al., Lercanidipine is an effective and well tolerated antihypertensive drug regardless the cardiovascular risk profile: The LAURA study. Int J Clin Pract, 2006. 60(11): p. 1364-70. [2]. Burnier, M., M. Pruijm, and G. Wuerzner, Treatment of essential hypertension with calcium channel blockers: what is the place of lercanidipine? Expert Opin Drug Metab Toxicol, 2009. 5(8): p. 981-7.

Density	1.2±0.1 g/cm3
Boiling Point	712.5±60.0 °C at 760 mmHg
Melting Point	118-120ºC
Molecular Formula	C₃₆H₄₁N₃O₆
Molecular Weight	611.727
Flash Point	384.7±32.9 °C
Exact Mass	611.299561
PSA	113.69000
LogP	8.04
Vapour Pressure	0.0±2.3 mmHg at 25°C
Index of Refraction	1.580

HS Code	2942000000

132866-11-6

~76%

100427-26-7

Literature: Recordati Ireland Limited Patent: US2006/199849 A1, 2006 ; Location in patent: Page/Page column 7-8 ;

28075-29-8

100427-26-7

Literature: European Journal of Medicinal Chemistry, , vol. 33, # 5 p. 399 - 420

74936-72-4

100427-26-7

Literature: European Journal of Medicinal Chemistry, , vol. 33, # 5 p. 399 - 420

100442-33-9

100427-26-7

Literature: European Journal of Medicinal Chemistry, , vol. 33, # 5 p. 399 - 420

100427-51-8

100427-26-7

Literature: European Journal of Medicinal Chemistry, , vol. 33, # 5 p. 399 - 420

88712-56-5

100442-33-9

100427-26-7

Literature: European Journal of Medicinal Chemistry, , vol. 33, # 5 p. 399 - 420

100427-53-0

21731-17-9

100427-26-7

Literature: US2006/199849 A1, ; Page/Page column 8 ;

21731-17-9

210579-45-6

100427-26-7

Literature: European Journal of Medicinal Chemistry, , vol. 33, # 5 p. 399 - 420

Precursor 9
132866-11-6 28075-29-8 74936-72-4 100442-33-9
100427-51-8 88712-56-5 100427-53-0 21731-17-9
210579-45-6
DownStream 1
132866-11-6

HS Code	2942000000

100427-26-7	957215-03-1
184866-29-3	887769-34-8
877372-41-3	210579-71-8
75130-24-4	74936-74-6
89267-42-5	1119226-97-9
1158522-08-7	2227854-02-4
940364-43-2	2648966-55-4
879946-43-7	2137743-65-6
2228834-72-6	134104-43-1
131615-57-1	6906-52-1