132866-11-6

132866-11-6 structure

Name: Lercanidipine hydrochloride
Chemical Name: Lercanidipine Hydrochloride
CAS Number: 132866-11-6
Molecular Formula: C₃₆H₄₂ClN₃O₆
Molecular Weight: 648.188
Catalog: Biochemical Chinese herbal medicine ingredients
Create Date: 2018-03-22 08:00:00
Modify Date: 2024-01-03 06:57:03
Lercanidipine hydrochloride is a calcium channel blocker of the dihydropyridine class.Target: Calcium ChannelLercanidipine is a calcium channel blocker of the dihydropyridine class, which works by relaxing and opening the blood vessels allowing the blood to circulate more freely around the body. Lercanidipine was effective and well-tolerated in patients with mild-to-moderate hypertension in the daily practice. The effectiveness and safety of the drug were independent of the degree of cardiovascular risk [1, 2].

Name	Lercanidipine Hydrochloride
Synonyms	Renovia Vasodip Carmen Lercadip Lercan Lercaton 2-((3,3-diphenylpropyl)methylamino)-1,1-dimethylethyl methyl (4RS)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate monohydrochloride Lercapin Lerdip Cardiovasc Lercanidipine hydrochloride Corifeo Lercanidipine hydrochloride hemihydrate Lerkamen Zanicor 1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride (1:1) Masnidipine hydrochloride REC 15-2375 1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methyl-2-propanyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate hydrochloride (1:1) Lerzam MFCD07773089 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester, hydrochloride (1:1) Zandip Zanidip Lercanidipine (hydrochloride)

Description	Lercanidipine hydrochloride is a calcium channel blocker of the dihydropyridine class.Target: Calcium ChannelLercanidipine is a calcium channel blocker of the dihydropyridine class, which works by relaxing and opening the blood vessels allowing the blood to circulate more freely around the body. Lercanidipine was effective and well-tolerated in patients with mild-to-moderate hypertension in the daily practice. The effectiveness and safety of the drug were independent of the degree of cardiovascular risk [1, 2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cardiovascular Disease
References	[1]. Barrios, V., et al., Lercanidipine is an effective and well tolerated antihypertensive drug regardless the cardiovascular risk profile: The LAURA study. Int J Clin Pract, 2006. 60(11): p. 1364-70. [2]. Burnier, M., M. Pruijm, and G. Wuerzner, Treatment of essential hypertension with calcium channel blockers: what is the place of lercanidipine? Expert Opin Drug Metab Toxicol, 2009. 5(8): p. 981-7.

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301
Precautionary Statements	P301 + P310
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T: Toxic;
Risk Phrases	R25
Safety Phrases	S36/37-S45
RIDADR	UN 2811

957215-03-1

~95%

132866-11-6

Literature: CF Pharma Ltd. Patent: EP1860102 A1, 2007 ; Location in patent: Page/Page column 1; 8; 15 ;

21731-17-9

~41%

132866-11-6

Literature: GLENMARK PHARMACEUTICALS LIMITED Patent: WO2007/31865 A2, 2007 ; Location in patent: Page/Page column 22-23 ;

929212-20-4

14205-39-1

132866-11-6

Literature: WO2008/107797 A2, ; Page/Page column 16 ;

100427-26-7

~88%

132866-11-6

Literature: RECORDATI IRELAND LIMITED Patent: WO2008/15248 A1, 2008 ; Location in patent: Page/Page column 7 ;

890045-70-2

28075-29-8

132866-11-6

Literature: WO2006/59332 A1, ; Example 3 ;