Shanghai Nianxing Industrial Co., Ltd
China
Product Name: trimetazidine dihydrochloride
Price: Check
Purity: 99.31%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: trimetazidine dihydrochloride
Price: ￥408.0/25g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Trimetazidine dihydrochloride
Price: $300.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Trimetazidine dihydrochloride
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: trimetazidine dihydrochloride
Price: ￥Inquiry/25kg
Purity: 99.0%
Stocking Period: Inquiry
Contact: Wang Jie
Email: 3096638339@qq.com

13171-25-0

13171-25-0 structure

Name: trimetazidine dihydrochloride
Chemical Name: Trimetazidine dihydrochloride
CAS Number: 13171-25-0
Molecular Formula: C₁₄H₂₄Cl₂N₂O₃
Molecular Weight: 339.258
Catalog: API Circulatory system medication Prevention and treatment of angina pectoris
Create Date: 2018-02-04 08:00:00
Modify Date: 2025-08-20 03:37:26
Trimetazidine dihydrochloride is a drug for angina pectoris. Trimetazidine is the first cytoprotective anti-ischemic agent , which improves myocardial glucose utilization through inhibition of fatty acid metabolism.

Name	Trimetazidine dihydrochloride
Synonyms	Trimetazidine Hydrochloride Piperazine, 1-[(2,3,4-trimethoxyphenyl)methyl]-, hydrochloride (1:2) Trimetazidine Dihydrochloride 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine,dihydrochloride Piperazine, 1-((2,3,4-trimethoxyphenyl)methyl)-, dihydrochloride (9CI) EINECS 236-117-0 1-(2,3,4-Trimethoxybenzyl)piperazine dihydrochloride MFCD00243086

Description	Trimetazidine dihydrochloride is a drug for angina pectoris. Trimetazidine is the first cytoprotective anti-ischemic agent , which improves myocardial glucose utilization through inhibition of fatty acid metabolism.
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Cardiovascular Disease

Boiling Point	364ºC at 760 mmHg
Melting Point	231-235 °C(lit.)
Molecular Formula	C₁₄H₂₄Cl₂N₂O₃
Molecular Weight	339.258
Flash Point	174ºC
Exact Mass	338.116394
PSA	42.96000
LogP	2.98830
Vapour Pressure	1.73E-05mmHg at 25°C
Storage condition	Refrigerator

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TM2976100

CHEMICAL NAME :: Piperazine, 1-(2,3,4-trimethoxybenzyl)-, dihydrochloride

CAS REGISTRY NUMBER :: 13171-25-0

LAST UPDATED :: 199009

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C14-H22-N2-O3.2Cl-H

MOLECULAR WEIGHT :: 339.30

WISWESSER LINE NOTATION :: T6M DNTJ D1R BO1 CO1 DO1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,527,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 345 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,527,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,527,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1550 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,527,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 305 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3262852

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 410 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,527,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3262852

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R22;R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	TM2976100
HS Code	2933499090

Precursor 0
DownStream 1
113594-65-3

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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