Name | Nestoron |
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Synonyms |
NESTORONE
19-Norpregn-4-ene-3,20-dione,17-hydroxy-16-methylene-,acetate 16-Methylene-17-hydroxy-19-norpregn-4-ene-3,20-dione acetate 17-(ACETYLOXY)-16-METHYLENE-19-NORPREGN-4-ENE-20-DIONE 17-Hydroxy-16-methylene-19-norpregn-4-ene-3,20-dione acetate Elcometrine |
Description | Nestoron(ST1435; Elcometrine) is a 19-norprogesterone derivative and steroidal progestin which is used as a hormonal contraceptive; a high-affinity agonist of the progesterone receptor. IC50 value:Tareget: progesterone receptorNestorone acts primarily as a high-affinity agonist of the progesterone receptor. It lacks significant affinity for the androgen receptor, and accordingly, does not produce any androgenic or anabolic effects. It does not bind to the estrogen receptor either. Nestorone does however have some affinity for the glucocorticoid receptor, where it appears to act as an agonist, but it does not appear to produce any glucocorticoid side effects unless used at high doses. Nestorone does not bind to sex hormone-binding globulin, and is instead bound to serum albumin. |
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Related Catalog | |
References |
Density | 1.15g/cm3 |
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Boiling Point | 499.3ºC at 760mmHg |
Molecular Formula | C23H30O4 |
Molecular Weight | 370.48200 |
Flash Point | 216.2ºC |
Exact Mass | 370.21400 |
PSA | 60.44000 |
LogP | 4.18520 |
Index of Refraction | 1.549 |
Storage condition | 2-8℃ |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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RIDADR | NONH for all modes of transport |
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