7759-35-5

• 常用中文名：醋酸烯诺孕酮
• 常用英文名：Nestoron
• CAS号：7759-35-5
• 分子式：C₂₃H₃₀O₄
• 分子量：370.48200
• 相关类别： 研究领域 内分泌
• 发布时间：2018-05-23 08:00:00
• 更新时间：2024-01-08 14:55:31
• Nestoron(ST1435; Elcometrine)是19-norprogesterone衍生物,是孕酮受体高亲和力激动剂。

名称

• 中文名: 醋酸烯诺孕酮
• 英文名: Nestoron
• 英文别名: NESTORONE; 19-Norpregn-4-ene-3,20-dione,17-hydroxy-16-methylene-,acetate; 16-Methylene-17-hydroxy-19-norpregn-4-ene-3,20-dione acetate; 17-(ACETYLOXY)-16-METHYLENE-19-NORPREGN-4-ENE-20-DIONE; 17-Hydroxy-16-methylene-19-norpregn-4-ene-3,20-dione acetate; Elcometrine

物化性质

• 密度: 1.15g/cm3
• 沸点: 499.3ºC at 760mmHg
• 分子式: C₂₃H₃₀O₄
• 分子量: 370.48200
• 闪点: 216.2ºC
• 精确质量: 370.21400
• PSA: 60.44000
• LogP: 4.18520
• 折射率: 1.549
• 储存条件: 2-8℃

生物活性

• 描述: Nestoron(ST1435; Elcometrine)是19-norprogesterone衍生物,是孕酮受体高亲和力激动剂。
• 相关类别:
  信号通路 >> 其他 >> 孕激素受体
  研究领域 >> 内分泌
  天然产物 >> 类固醇
• 参考文献:

  [1]. Ilani N, et al. A New Combination of Testosterone and Nestorone Transdermal Gels for Male Hormonal Contraception.J Clin Endocrinol Metab. 2012 Jul 12.

  [2]. Rad M, et al. Discriminant analysis of the metabolic effects of a new combined contraceptive vaginal ring containing Nestorone/EE vs. a second-generation oral contraceptive containing levonorgestrel/EE.Contraception. 2012 Sep;86(3):231-7. Epub 2012 Mar 23

  [3]. Hussain R, et al. Progesterone and Nestorone facilitate axon remyelination: a role for progesterone receptors.Endocrinology. 2011 Oct;152(10):3820-31. Epub 2011 Aug 9.

  [4]. Prasad PV, et al. Single-dose pharmacokinetics of Nestorone, a potential female-contraceptive.Steroids. 2010 Mar;75(3):252-64. Epub 2010 Jan 11.

  [5]. Elsimar M Coutinho et al. Use of a single implant of elcometrine (ST-1435), a nonorally active progestin, as a long acting contraceptive for postpartum nursing women Contraception Volume 59, Issue 2, February 1999, Pages 115-122

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : RC8960750 CHEMICAL NAME : 19-Norpregn-4-ene-3,20-dione, 17-hydroxy-16-methylene-, acetate CAS REGISTRY NUMBER : 7759-35-5 LAST UPDATED : 199306 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C23-H30-O4 MOLECULAR WEIGHT : 370.53 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Administration onto the skin DOSE : 240 ug/kg SEX/DURATION : female 24 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - menstrual cycle changes or disorders REFERENCE : FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 58,680,1992 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Implant DOSE : 800 ug/kg SEX/DURATION : female 56 week(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - other measures of fertility REFERENCE : CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 25,299,1982 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Implant DOSE : 2200 ug/kg SEX/DURATION : female 43 week(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - menstrual cycle changes or disorders Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) REFERENCE : CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 18,411,1978 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Implant DOSE : 700 ug/kg SEX/DURATION : female 26 week(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - menstrual cycle changes or disorders REFERENCE : FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 36,737,1981

安全

• 危险品运输编码: NONH for all modes of transport