63701-55-3

63701-55-3 structure

Name: (R)-Baclofen (hydrochloride)
Chemical Name: (3R)-4-amino-3-(4-chlorophenyl)butanoic acid,hydrochloride
CAS Number: 63701-55-3
Molecular Formula: C₁₀H₁₃Cl₂NO₂
Molecular Weight: 250.12200
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
Create Date: 2018-05-26 08:00:00
Modify Date: 2024-01-02 09:29:09
(R)-Baclofen Hcl(STX-209 Hcl) is a derivative of gamma-aminobutyric acid (GABA) primarily used to treat spasticity and is in the early research stages for use for the treatment of alcoholism.Target: GABABaclofen (brand names Kemstro, Lioresal, Liofen, Gablofen, Beklo and Baclosan) is a derivative of gamma-aminobutyric acid (GABA). It is primarily used to treat spasticity and is in the early research stages for use for the treatment of alcoholism. It is also used by compounding pharmacies in topical pain creams as a muscle relaxant.It is an agonist for the GABAB receptors. Its beneficial effects in spasticity result from actions at spinal and supraspinal sites. Baclofen can also be used to treat hiccups, and has been shown to prevent rises in body temperature induced by the drug MDMA in rats.In addition, research has shown baclofen to be effective in the treatment of alcohol dependence and withdrawal, by inhibiting both withdrawal symptoms andcravings.

Name	(3R)-4-amino-3-(4-chlorophenyl)butanoic acid,hydrochloride
Synonyms	Arbaclofen HCl d-Baclofen hydrochloride MFCD00078579 Arbaclofen hydrochloride (R)-Baclofen (hydrochloride)

Description	(R)-Baclofen Hcl(STX-209 Hcl) is a derivative of gamma-aminobutyric acid (GABA) primarily used to treat spasticity and is in the early research stages for use for the treatment of alcoholism.Target: GABABaclofen (brand names Kemstro, Lioresal, Liofen, Gablofen, Beklo and Baclosan) is a derivative of gamma-aminobutyric acid (GABA). It is primarily used to treat spasticity and is in the early research stages for use for the treatment of alcoholism. It is also used by compounding pharmacies in topical pain creams as a muscle relaxant.It is an agonist for the GABAB receptors. Its beneficial effects in spasticity result from actions at spinal and supraspinal sites. Baclofen can also be used to treat hiccups, and has been shown to prevent rises in body temperature induced by the drug MDMA in rats.In addition, research has shown baclofen to be effective in the treatment of alcohol dependence and withdrawal, by inhibiting both withdrawal symptoms andcravings.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Research Areas >> Neurological Disease
References	[1]. Mezler M, et al. Cloning and functional expression of GABA(B) receptors from Drosophila. Eur J Neurosci. 2001 Feb;13(3):477-86. [2]. Dzitoyeva S, et al. Gamma-aminobutyric acid B receptor 1 mediates behavior-impairing actions of alcohol in Drosophila: adult RNA interference and pharmacological evidence. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5485-90. Epub 2003 Apr 11.

Boiling Point	364.3ºC at 760 mmHg
Molecular Formula	C₁₀H₁₃Cl₂NO₂
Molecular Weight	250.12200
Flash Point	174.1ºC
Exact Mass	249.03200
PSA	63.32000
LogP	3.35930

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MW5084350

CHEMICAL NAME :: Hydrocinnamic acid, beta-(aminomethyl)-p-chloro-, hydrochloride, (R)-

CAS REGISTRY NUMBER :: 63701-55-3

LAST UPDATED :: 198503

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H12-Cl-N-O2.Cl-H

MOLECULAR WEIGHT :: 250.14

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 523 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 32,187,1980

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	S24/25
RIDADR	UN 2811 6.1/PG 3
RTECS	MW5084350

Precursor 8
123632-35-9 290366-79-9 1201795-62-1 188635-62-3
537676-64-5 101671-01-6 104-88-1 1042939-73-0
DownStream 1
69308-37-8

63701-55-3	290366-79-9
69308-37-8	63701-56-4
71-68-1	2912-80-3
28311-31-1	167144-80-1
82864-02-6	95530-85-1