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2284-31-3

2284-31-3 structure
2284-31-3 structure
  • Name: Pratensein
  • Chemical Name: pratensein
  • CAS Number: 2284-31-3
  • Molecular Formula: C16H12O6
  • Molecular Weight: 300.26300
  • Catalog: Research Areas Neurological Disease
  • Create Date: 2018-03-24 08:00:00
  • Modify Date: 2024-01-05 11:44:15
  • Pratensein, a flavonoid, ameliorates β-amyloid-induced cognitive impairment in rats via reducing oxidative damage and restoring synapse and BDNF levels[1].

Name pratensein
Synonyms 5,7,3'-trihydroxy-4'-methoxyisoflavone
5,7-dihydroxy-3-(3-hydroxy-4-methoxyphenyl)chromen-4-one
3',5,7-trihydroxy-4'-methoxyisoflavone
Pratensein
5,7,5'-trihydroxy-4'-methoxyisoflavone
3'-hydroxy-biochanin A
Description Pratensein, a flavonoid, ameliorates β-amyloid-induced cognitive impairment in rats via reducing oxidative damage and restoring synapse and BDNF levels[1].
Related Catalog
In Vivo Pratensein significantly attenuates neuronal degeneration and apoptosis in hippocampus. The over-expression in IL-1β and TNF-α as well as the extensive astrogliosis and microgliosis in hippocampus induced by Aβ1-42 are significantly reduced following administration of Pratensein. Pratensein treatment significantly suppresses the activation of NF-κB in hippocampus. Pratensein is able to increase the levels of synaptophysin and brain-derived neurotrophic factor (BDNF)[1]. Pratensein (20 mg/kg; p.o.; once daily for 3 weeks) ameliorates learning and memory deficits in Aβ1-42 rat model of Alzheimer’s disease[1]. Animal Model: Male 10-week old Wistar rats[1] Dosage: 20 mg/kg Administration: P.o.; once daily for 3 weeks Result: The spatial learning and memory ability of rats was improved.
References

[1]. Liang C, et al. Pratensein ameliorates β-amyloid-induced cognitive impairment in rats via reducing oxidative damage and restoring synapse and BDNF levels. Neurosci Lett. 2015;592:48-53.

Density 1.512g/cm3
Boiling Point 576.7ºC at 760mmHg
Melting Point 271-273 °C
Molecular Formula C16H12O6
Molecular Weight 300.26300
Flash Point 220.3ºC
Exact Mass 300.06300
PSA 100.13000
LogP 2.58540
Vapour Pressure 6.73E-14mmHg at 25°C
Index of Refraction 1.697
Hazard Codes Xi
HS Code 2914509090

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2284-31-3 structure

2284-31-3

Literature: Jain, A. C.; Bambah, P. K. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1987 , vol. 26, # 1-12 p. 488 - 490

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2284-31-3 structure

2284-31-3

Literature: Jain, A. C.; Bambah, P. K. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1987 , vol. 26, # 1-12 p. 488 - 490
Precursor  3

DownStream  0

HS Code 2914509090
Summary HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%