158018-81-6

158018-81-6 structure

Name: Mal-amino-sulfo
Chemical Name: sulfo-n-succinimidyl 4-maleimido
CAS Number: 158018-81-6
Molecular Formula: C₁₂H₁₂N₂O₉S
Molecular Weight: 360.29700
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2017-04-29 00:04:53
Modify Date: 2024-01-09 13:38:45
Mal-amino-sulfo is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	sulfo-n-succinimidyl 4-maleimido
Synonyms	N-[(1S)-1-carboxy-2-cyanoethyl]-L-glutamine

Description	Mal-amino-sulfo is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.