134272-63-2
134272-63-2 structure
- Name: Mal-NH-Boc
- Chemical Name: tert-butyl N-[2-(2,5-dioxopyrrol-1-yl)ethyl]carbamate
- CAS Number: 134272-63-2
- Molecular Formula: C11H16N2O4
- Molecular Weight: 240.25600
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2019-01-01 19:35:23
- Modify Date: 2025-08-25 13:07:02
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Mal-NH-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
| Name | tert-butyl N-[2-(2,5-dioxopyrrol-1-yl)ethyl]carbamate |
|---|---|
| Synonyms |
[2-(2,5-DIOXO-2,5-DIHYDRO-PYRROL-1-YL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER
N-(2-((tert-butoxycarbonyl)amino)ethyl)-maleimide N-(tert.-butyloxycarbonyl)-2-(N-maleinimido)ethylamine N-Boc-2-Maleimidoethylamine tert-Butyl (2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)carbamate N-BOC-2-malemidoethylamine 1-((N-tert-butoxycarbonyl)-2-aminoethyl)maleimide N-[2-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-ethyl]-carbamic acid tert-butyl ester 2-(maleimido)ethylcarbamic acid tert-butyl ester N-(2-[(Boc)amino]ethyl)maleimide |
| Description | Mal-NH-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
Alkyl/ether |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Melting Point | 110-115 °C |
|---|---|
| Molecular Formula | C11H16N2O4 |
| Molecular Weight | 240.25600 |
| Exact Mass | 240.11100 |
| PSA | 75.71000 |
| LogP | 0.76490 |
| Hazard Codes | Xi |
|---|---|
| HS Code | 2925190090 |
|
~48%
134272-63-2 |
| Literature: Richter, Martin; Chakrabarti, Alokta; Ruttekolk, Ivo R.; Wiesner, Burkhard; Beyermann, Michael; Brock, Roland; Rademann, Joerg Chemistry - A European Journal, 2012 , vol. 18, # 52 p. 16708 - 16715 |
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| Literature: US5180816 A1, ; |
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134272-63-2 |
| Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 21 p. 2843 - 2848 |
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134272-63-2 |
| Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 20 p. 2975 - 2982 |
|
~81%
134272-63-2 |
| Literature: Antczak; Bauvois; Monneret; Florent Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 21 p. 2843 - 2848 |
|
~92%
134272-63-2 |
| Literature: Boehringer Mannheim GmbH Patent: US5595741 A1, 1997 ; |
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| Literature: WO2011/9047 A2, ; Page/Page column 16-17 ; |
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~59%
134272-63-2 |
| Literature: Foley, Timothy L.; Yasgar, Adam; Garcia, Christopher J.; Jadhav, Ajit; Simeonov, Anton; Burkart, Michael D. Organic and Biomolecular Chemistry, 2010 , vol. 8, # 20 p. 4601 - 4606 |
| Precursor 7 | |
|---|---|
| DownStream 1 | |
| HS Code | 2925190090 |
|---|---|
| Summary | 2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |