CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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QK2705000
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CHEMICAL NAME :
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1-Naphthalenesulfonic acid, 4-hydroxy-3-((6-sulfo-2,4-xylyl)azo)-, disodium salt
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CAS REGISTRY NUMBER :
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4548-53-2
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LAST UPDATED :
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199701
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DATA ITEMS CITED :
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14
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MOLECULAR FORMULA :
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C18-H14-N2-O7-S2.2Na
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MOLECULAR WEIGHT :
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480.44
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WISWESSER LINE NOTATION :
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L66J BQ CNUNR B D ESWO& ESWO &-NA- 2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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>2 gm/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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MEIEDD Merck Index. (Merck & Co., Inc., Rahway, NJ 07065) 10th ed. 1983. For publisher information, see 85KYAH. Volume(issue)/page/year: 11,1209,1989 ** OTHER MULTIPLE DOSE TOXICITY DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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182 gm/kg/1Y-C
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TOXIC EFFECTS :
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Related to Chronic Data - death
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REFERENCE :
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TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 8,306,1966
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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1277 gm/kg/7Y-C
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TOXIC EFFECTS :
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Kidney, Ureter, Bladder - inflammation, necrosis, or scarring of bladder Endocrine - other changes Related to Chronic Data - death
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REFERENCE :
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TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 8,306,1966 ** TUMORIGENIC DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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1200 gm/kg/78W-C
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Blood - lymphoma, including Hodgkin's disease
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REFERENCE :
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GASTAB Gastroenterology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1943- Volume(issue)/page/year: 23,1,1953
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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524 gm/kg/73W-C
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TOXIC EFFECTS :
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Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors Blood - lymphoma, including Hodgkin's disease
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REFERENCE :
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VPITAR Voprosy Pitaniya. Problems of Nutrition. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1932-41; V.11- 1952- Volume(issue)/page/year: 29,61,1970 *** REVIEWS *** IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,207,1975 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,207,1975 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI. Volume(issue)/page/year: 14,127,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M3844 No. of Facilities: 76 (estimated) No. of Industries: 3 No. of Occupations: 6 No. of Employees: 881 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M3844 No. of Facilities: 768 (estimated) No. of Industries: 5 No. of Occupations: 7 No. of Employees: 13674 (estimated) No. of Female Employees: 1853 (estimated)
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