7758-09-0

MOLECULAR WEIGHT :

85.11

WISWESSER LINE NOTATION :

.KA..N-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human

DOSE/DURATION :

1428 ug/kg

TOXIC EFFECTS :

Sense Organs and Special Senses (Ear) - tinnitus Cardiac - pulse rate increase, without fall in BP Vascular - BP lowering not characterized in autonomic section

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

85 gm/m3/2H

TOXIC EFFECTS :

Behavioral - sleep Behavioral - excitement Behavioral - muscle contraction or spasticity

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

200 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

18 gm/kg/13W-C

TOXIC EFFECTS :

Blood - pigmented or nucleated red blood cells Blood - methemoglobinemia-carboxyhemoglobin Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

30 gm/kg

SEX/DURATION :

male 60 day(s) pre-mating female 60 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

137 gm/kg

SEX/DURATION :

female 18 week(s) pre-mating

TOXIC EFFECTS :

Reproductive - Effects on Newborn - stillbirth

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

201 gm/kg

SEX/DURATION :

female 19 week(s) pre-mating

TOXIC EFFECTS :

Reproductive - Fertility - abortion Reproductive - Effects on Embryo or Fetus - other effects to embryo

MUTATION DATA

TYPE OF TEST :

DNA inhibition

TEST SYSTEM :

Microorganism - not otherwise specified

DOSE/DURATION :

20 mmol/L

REFERENCE :

JMOBAK Journal of Molecular Biology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 5,442,1962 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83413 No. of Facilities: 205 (estimated) No. of Industries: 11 No. of Occupations: 7 No. of Employees: 1353 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83413 No. of Facilities: 788 (estimated) No. of Industries: 22 No. of Occupations: 34 No. of Employees: 27303 (estimated) No. of Female Employees: 2845 (estimated)