264622-53-9

264622-53-9 structure

Name: MRS 1706
Chemical Name: N-(4-acetylphenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide
CAS Number: 264622-53-9
Molecular Formula: C₂₇H₂₉N₅O₅
Molecular Weight: 503.55000
Catalog: Signaling Pathways GPCR/G Protein Adenosine Receptor
Create Date: 2018-12-18 14:15:14
Modify Date: 2024-01-02 13:43:34
MRS-1706 is a potent and selective A(2B) adenosine receptor antagonist with a Ki value of 1.39 nM.

Name	N-(4-acetylphenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide
Synonyms	MRS 1706 Tocris-1584 MRS-1706

Description	MRS-1706 is a potent and selective A(2B) adenosine receptor antagonist with a Ki value of 1.39 nM.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor Research Areas >> Inflammation/Immunology
Target	IC50: 1.39 nM (A(2B) human adenosine receptor)[1].
In Vitro	MRS-1706 is a selective adenosine A2B receptor inverse agonist with Ki values of 1.39, 157, 112, and 230 nM for human A2B, A1, A2A, and A3 receptors, respectively[1]. Pretreatment with ZM241385 (A2A-Ado receptor antagonist) alone or in combination with MRS-1706 (A2B-Ado receptor antagonist) results in a pure constriction upon adenosine[2].
References	[1]. Kim YC, et al. Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A(2B) adenosine receptors. J Med Chem. 2000 Mar 23;43(6):1165-72. [2]. Lai EY, et al. Contribution of adenosine receptors in the control of arteriolar tone and adenosine-angiotensin II interaction. Kidney Int. 2006 Aug;70(4):690-8.