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33386-08-2

33386-08-2 structure

33386-08-2 structure

Name: Buspirone hydrochloride
Chemical Name: buspirone hydrochloride
CAS Number: 33386-08-2
Molecular Formula: C₂₁H₃₂ClN₅O₂
Molecular Weight: 421.96400
Catalog: API Nervous system medication Anxiolytic
Create Date: 2018-08-02 10:18:58
Modify Date: 2026-06-30 18:37:46
Buspirone hydrochloride is an anxiolytic psychotropic drug, is used to treat generalized anxiety disorder (GAD).

Name	buspirone hydrochloride
Synonyms	5,6-DICHLORO-2-(ISOPROPYLAMINO)-1-(BETA-L-RIBOFURANOSYL)-LH-BENZIMIDAZOLE 8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione,hydrochloride 8-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)-8-azaspirodecane-7,9-dione, hydrochloride (1:1) MFCD00078569 censp Birone HCl (MJ90221) 8-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-8-azaspirodecane-9-dione 8-(4-(4-(Pyrimidin-2-yl)piperazin-1-yl)butyl)-8-azaspirodecane-7,9-dione hydrochloride Birone hydrochloride BIRONE HCL Birone (hydrochloride) (CRM) Birone hydrochloride, 5-HT1A agonist BIRONEHYDROCHLORIDE Birone Hydrochlorid Nol 8-[4-[4-(2-Pyrimidinyl)-1-pipirazinyl]butyl]-8-azaspiro[4,5]decane-7,9-dionehydrochloride N-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-8-azaspirodecan-7,9-dione hydrochloride N-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-1,1-cyclopentanediacetimide hydrochloride binol 8-(4-(4-(2-Pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dione hydrochloride Birone Hydrochloride 8-[4-[4-(Pyrimidin-2-yl)piperazin-1-yl]butyl]-8-azaspiro- decane-7,9-dione hydrochloride bironechloridate Buspirone Hydrochloride Birone hydrochloride, 10 mM in DMSO 8-[4-[4-(2-pyrimidinyl)-1-piperazin-1-iumyl]butyl]-8-azaspirodecane-7,9-dione 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspirodecane-7,9-dione monohydrochloride Birone HCl (MJ90221) HCl Birone HydrochlorideQ: What is Birone Hydrochloride Q: What is the CAS Number of Birone Hydrochloride Q: What is the storage condition of Birone Hydrochloride Q: What e the applications of Birone Hydrochloride 8-Azaspirodecane-7,9-dione,8-[4-[4-(2-pyriMidinyl)-1-piperazinyl]butyl]-, hydrochloride (1:1) Birone Hydrochloride 1.0 mg/ml in Methanol (as free base) Birone hydrochloride,N-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-8-azaspirodecane-7,9-dione hydrochloride besp 8-[4-[4-(2-PYRIMIDINYL)-1-PIPERAZINYL]BUTYL]-8-AZASPIRO[4,5]DECANE-7,9-DIONE HYDROCHLORIDE Birone hydrochloride solution N-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride Ansiced Birone HCl - Bio-X axoren N-[4-(4-[2-PYRIMIDINYL]-1-PIPERAZINYL)BUTYL]-8-AZASPIRO[4,5]DECANE-7,9-DIONE HYDROCHLORIDE Ansial 3-[4-[4-(2-Pyrimidinyl)piperazino]butyl]-3-azaspirodecane-2,4-dione·hydrochloride 1-Cyclopentanediacetimide,N-(4-(4-( lucelan Birone hydrochloride in Methanol Birone.HCl, 1mg/ml in Methanol (as free base) mj9022-1 1-cyclopentanediacetimide,n-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-h Birone for system suitability(Secondy Standds traceble to EINECS 251-489-4 Birone hydrochloride //BP Birone hydrochloride CRS 8-Azaspiro4.5decane-7,9-dione, -4-(2-pyrimidinyl)-1-piperazinylbutyl-, monohydrochloride travin

Description	Buspirone hydrochloride is an anxiolytic psychotropic drug, is used to treat generalized anxiety disorder (GAD).
Related Catalog	Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Research Areas >> Neurological Disease

Density	1.24g/cm3
Boiling Point	613.9ºC at 760mmHg
Melting Point	201.5-202.50C
Molecular Formula	C₂₁H₃₂ClN₅O₂
Molecular Weight	421.96400
Flash Point	325.1ºC
Exact Mass	421.22400
PSA	69.64000
LogP	2.83100
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CL9915000

CHEMICAL NAME :: 8-Azaspiro(4.5)decane-7,9-dione, 8-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-, monohydrochloride

CAS REGISTRY NUMBER :: 33386-08-2

LAST UPDATED :: 199612

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C21-H31-N5-O2.Cl-H

MOLECULAR WEIGHT :: 422.03

WISWESSER LINE NOTATION :: T6VNV EXTJ E-& AL5XTJ& B4- AT6N DNTJ D- BT6N CNJ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 4 mg/kg/2W-I

TOXIC EFFECTS :: Behavioral - euphoria

REFERENCE :: BJPYAJ British Journal of Psychiatry. (Headley Brothers, Ltd., Ashford, Kent TN24 8HH, UK) V.109- 1963- Volume(issue)/page/year: 158,136,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 196 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 23,311,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 136 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,917,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 655 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 23,311,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 146 mg/kg

TOXIC EFFECTS :: Behavioral - antipsychotic Behavioral - alteration of classical conditioning

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 15,477,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 586 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 23,311,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 356 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 23,311,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 140 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 25,193,1991 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 58 mg/kg

SEX/DURATION :: male 26 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - other effects on male

REFERENCE :: SMJOAV Southern Medical Journal. (Southern Medical Assoc., POB 2446, Birmingham, AL 35205) V.1- 1908- Volume(issue)/page/year: 83,983,1990

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 825 mg/kg

SEX/DURATION :: female 7-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 15(Suppl 1),31,1990

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 825 mg/kg

SEX/DURATION :: female 7-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - other postnatal measures or effects

REFERENCE :: JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 15(Suppl 1),61,1990

Symbol	GHS02, GHS06, GHS08
Signal Word	Danger
Hazard Statements	H225-H301 + H311 + H331-H370
Precautionary Statements	P210-P260-P280-P301 + P310-P311
Hazard Codes	T:Toxic;
Risk Phrases	R25
Safety Phrases	S45
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	CL9915000
HS Code	2933990090

Precursor 4
110-52-1 20980-22-7 1075-89-4 1359159-58-2
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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